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EC number: 203-424-6 | CAS number: 106-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19.07.1993 to 21.07.1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexane-1,2,6-triol
- EC Number:
- 203-424-6
- EC Name:
- Hexane-1,2,6-triol
- Cas Number:
- 106-69-4
- Molecular formula:
- C6H14O3
- IUPAC Name:
- hexane-1,2,6-triol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: Rat / Sprague-Dawley
- Number and sex: 10 animals (5 males and 5 females)
- Body weigth: Males 214 - 233 g, Females 207 - 229 g
- Age: young
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS:
- Diet:Rat and Mouse Expanded Diet No. 1 (Special Diet Services Limited, Witham, Essex, U.K.)
- Water: tab water ad libitum
- Housing in groups of 5 animals in polypropylene cages
- Temperature: 19-23°C
- Rel. Humidity: 48-66%
- Light/dark period: 12/12h
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: distilled water (10 %)
- Mass median aerodynamic diameter (MMAD):
- 2 µm
- Geometric standard deviation (GSD):
- 0.38
- Remark on MMAD/GSD:
- The particle size of the generated atmosphere of the test material inside the exposure chamber was determined at least twice during the exposure period using a Cascade Impactor.
The respirable fraction was 75.6 % (< 4 µm). - Details on inhalation exposure:
- Prior to the start of the study the test material was formulated with 10% distilled water to facilitate aerolisation. The test material formulation was then aerosolised using a glass concentric jet nebuliser (Radleys, Saffron Walden, Essex) located at the top of the exposure chamber. The nebuliser was connected to a glass syringe attached to a modified infusion pump, which provided a continuous supply of test material under pressure, and to a metered compressed air supply. Prior to the start of the study test material atmospheres were generated within the exposure chamber. During these periods air flow settings, test material input and the sampling system were varied to achieve the required atmospheric concentrations. The chamber flow rate was maintained at 14 L/min providing 28 air changes per hour.
During the exposure period each rat was individually held in a tapered, polycarbonate res training tube fitted onto a single tier of the exposure chamber and sealed by means of a rubber 'O' ring . Only the noses of the animals were exposed to the test atmosphere.
A single group of ten rats (five males and five females) was exposed to an atmosphere of the test material for a period of four hours. A target concentration of 5 mg/litre was used for the exposure . No deaths occurred and therefore no further levels were required. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Nominal: 89.9 mg/L
Mean dose achieved: 5.07 mg/L - No. of animals per sex per dose:
- 5 male / 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.07 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred during the observation period of 14 days.
- Clinical signs:
- other: During exposure wet fur was common. On removal from the chamber all animals showed hunched posture and pilo-erection and there were incidents of decreased respiratory rate, ptosis and red/brown staining around the head. One hour after completion of exposu
- Body weight:
- All animals showed expected bodyweight development during the study.
- Gross pathology:
- No abnormalities were detected at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No deaths occurred in a group of ten rats exposed to a mean achieved concentration of 5.07 mg/L (range 3.93 - 5.46 mg/litre). It was therefore considered that the acute inhalation median lethal concentration (LC50) of the test material in the Sprague-Dawley strain rat was greater than 5.07 mg/litre.Thus, according to Regulation (EC) 1272/2008 the data are conclusive but not sufficient for classification.
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