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EC number: 257-151-2 | CAS number: 51357-74-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from safety assessment report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Fiber Reactive Dyes Toxicological Profiles December 1981
- Author:
- U.S. Consumer Product Safety Commission
- Year:
- 1 981
- Bibliographic source:
- Fiber Reactive Dyes Toxicological Profiles December 1981, PB83-168732
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess eye irritation potential of Benzoic acid,2-((((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2 , 5-disulfophenyl)amino)- 1,3,5-triazin-2-yl) amino)-2-hydroxy- 5sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt on rabbit eye
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Benzoic acid2-(3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)- 1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)- 1,3,5-triazin-2-yl)amino) -2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt
- EC Number:
- 615-670-5
- Cas Number:
- 71872-76-9
- Molecular formula:
- C38H28Cl2N14O18S5.5Na
- IUPAC Name:
- Benzoic acid2-(3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)- 1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)- 1,3,5-triazin-2-yl)amino) -2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt
- Test material form:
- solid
- Details on test material:
- IUPAC: Benzoic acid, 2-((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt
common name: C.I. Reactive Blue 160
Molecular formula :C38H28Cl2N14O18S5.5Na
Molecular weight :1309.87
Substance type:organic
Physical state:solid
InChI:1S/C38H28Cl2N14O18S5.5Na/c39-33-45-35(41-18-7-4-8-19(11-18)73(58,59)60)49-36(46-33)42-24-15-29(77(70,71)72)25(16-28(24)76(67,68)69)43-37-47-34(40)48-38(50-37)44-26-13-21(75(64,65)66)14-27(30(26)55)52-54-31(17-5-2-1-3-6-17)53-51-23-10-9-20(74(61,62)63)12-22(23)32(56)57;;;;;/h1-16,31,55H,(H,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H2,41,42,45,46,49)(H2,43,44,47,48,50);;;;;/q;5*+1/p-5/b53-51+,54-52+;;;;;
Smiles:[Na+].[Na+].[Na+].[Na+].[Na+].C(c1c(ccc(c1)S(=O)(=O)[O-])\N=N\[C@@H](c1ccccc1)\N=N\c1c(c(cc(c1)S(=O)(=O)[O-])Nc1nc(nc(n1)Cl)Nc1c(cc(c(c1)S(=O)(=O)[O-])Nc1nc(nc(n1)Cl)Nc1cc(ccc1)S(=O)(=O)O)S(=O)(=O)[O-])O)(=O)[O-]
Constituent 1
- Specific details on test material used for the study:
- IUPAC: Benzoic acid, 2-((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt
common name: C.I. Reactive Blue 160
Molecular formula :C38H28Cl2N14O18S5.5Na
Molecular weight :1309.87
Substance type:organic
Physical state:solid
InChI:1S/C38H28Cl2N14O18S5.5Na/c39-33-45-35(41-18-7-4-8-19(11-18)73(58,59)60)49-36(46-33)42-24-15-29(77(70,71)72)25(16-28(24)76(67,68)69)43-37-47-34(40)48-38(50-37)44-26-13-21(75(64,65)66)14-27(30(26)55)52-54-31(17-5-2-1-3-6-17)53-51-23-10-9-20(74(61,62)63)12-22(23)32(56)57;;;;;/h1-16,31,55H,(H,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)(H2,41,42,45,46,49)(H2,43,44,47,48,50);;;;;/q;5*+1/p-5/b53-51+,54-52+;;;;;
Smiles:[Na+].[Na+].[Na+].[Na+].[Na+].C(c1c(ccc(c1)S(=O)(=O)[O-])\N=N\[C@@H](c1ccccc1)\N=N\c1c(c(cc(c1)S(=O)(=O)[O-])Nc1nc(nc(n1)Cl)Nc1c(cc(c(c1)S(=O)(=O)[O-])Nc1nc(nc(n1)Cl)Nc1cc(ccc1)S(=O)(=O)O)S(=O)(=O)[O-])O)(=O)[O-]
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: Not specified
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- positive indication of ocular reactions were noticed
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Eye irritation reactions were observed when Benzoic acid, 2-((((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt was installed on rabbit eyes.
Hence ,Benzoic acid, 2-((((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt was considered to be irritating to rabbit eyes.
- Executive summary:
The ocular irritation potential of Benzoic acid, 2-((((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)-1,3,5-triazin-2-yl)amino) -2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt on rabbit eye.
Positive ocular irritation reactions were observed. Hence, Benzoic acid, 2-((((3-((4-chloro-6-((4-((4-chloro-6-((3-sulfophenyl)amino)- 1,3,5-triazin-2-yl)amino)-2,5-disulfophenyl)amino)-1,3,5-triazin-2-yl)amino)-2-hydroxy-5 sulfophenyl)azo)phenylmethyl)azo)-5-sulfo-,pentasodium salt was considered to be irritating to rabbit eye.
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