Registration Dossier
Registration Dossier
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EC number: 202-000-8 | CAS number: 90-51-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR: read-across performed with the OECD QSAR Toolbox
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-10-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the attached QPRF report
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- OECD QSAR Toolbox version 4.1
- Author:
- OECD
- Year:
- 2 008
- Bibliographic source:
- The Toolbox is a software for filling gaps in (eco)toxicity data. The Toolbox incorporates information and tools from various sources into a logical workflow. Crucial to this workflow is grouping chemicals into chemical categories.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
Test material
- Reference substance name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- EC Number:
- 202-000-8
- EC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
- Cas Number:
- 90-51-7
- Molecular formula:
- C10H9NO4S
- IUPAC Name:
- 6-amino-4-hydroxynaphthalene-2-sulphonic acid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Parameter:
- other: QSAR
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
Gammasäure is predicted to be sensitising by the OECD QSAR Toolbox v4.1. This prediction does not fall into the applicability domain of this model, since the read-across is based only on one analogue substance.
Applicant's summary and conclusion
- Interpretation of results:
- other: data not sufficient for classification
- Conclusions:
- Gammasäure is predicted to be sensitising.
- Executive summary:
Skin sensitisation of Gammasäure was predicted using the OECD QSAR Toolbox v4.1. The read-across analysis was performed with one analogue substance. The logKow was used as 'active descriptor'. The prediction is positive. Due to the fact that only one analogue was used for the prediction, it does not fall into the applicability domain of this model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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