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EC number: 274-356-2 | CAS number: 70161-20-5
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on aquatic invertebrate predicted for Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5). Effect concentration i.e EC50 value estimated to be 274.631 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) is likely to be not toxic to aquatic invertebrate, hence it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.
Toxicity to aquatic algae and cyanobacteria
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on aquatic algae predicted for Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5). Effect concentration i.e EC50 value estimated to be 138.48 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It can be concluded that the Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) is likely to be not toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
Additional information
Short-term toxicity to aquatic invertebrates
Following three studies of target chemical and structurally similar read across includes predicted data and experimental data to conclude the toxicity extent of Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) towards aquatic invertebrate is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on aquatic invertebrate predicted for Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5). Effect concentration i.e EC50 value estimated to be 274.631 mg/l for Daphnia magna for 48 hrs duration. It can be concluded that the Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) is likely to be not toxic to aquatic invertebrate, hence it can be considered to be“not classified”as per the CLP classification criteria for aquatic environment.
The above predicted data of target chemical is supported by the experimental study of structurally similar read across Benzyl alcohol (CAS:100-51-6) from the authoritative database J-Check 2017 suggests that the Short term toxicity to aquatic invertebrate was carried out according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) for Benzyl alcohol. The effective concentration EC50 to 50% of Daphnia magna when exposed to Benzyl alcohol for 48 hr is 230 mg/L. It can be concluded from the value that the Benzyl alcohol is not toxic to the aquatic invertebrate and can be considered as “not classified” as per the classification criteria for aquatic environment.
Thus based on the effect concentrations which is in the range 230 mg/L mg/l to 274.631mg/l give the conclusion that test substance Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) was likely to be not toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered to be “not classified”as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria
Following three studies of target chemical and structurally similar read across includes predicted data and experimental data to conclude the toxicity extent of Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) towards aquatic algae is summarized as follows:
Based on the prediction done using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the closest read across substances, the toxicity on aquatic algae predicted for Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5). Effect concentration i.e EC50 value estimated to be 138.48 mg/l for Pseudokirchneriella subcapitata for 72 hrs duration. It can be concluded that the Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) is likely to be not toxic to aquatic algae, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.
The above predicted data of target chemical is supported by the experimental study of structurally similar read across Benzyl alcohol (CAS:100-51-6) from the authoritative database J-Check 2017 suggests that the Toxicity to aquatic algae and cyanobacteria according to the OECD Guideline 201 (Alga, Growth Inhibition Test) to study the effects of Benzyl alcohol. The effective concentration to 50 % of algae when exposed to Benzyl alcohol for 72 h is 770 mg/L. It can be concluded from the growth rate value that the Benzyl alcohol is not toxic to the aquatic algae can be considered as “not classified” as per the classification criteria for aquatic environment.
Thus based on the effect concentrations which is in the range 138.48 mg/L mg/l to 770 mg/l give the conclusion that test substance Trisodium [2-[[alpha-[[2-hydroxy-5-sulpho-3-[(2,5,6-trichloro- 4-pyrimidinyl)amino]phenyl]azo]benzyl]azo]-5-sulphobenzoato(5-)]cupra (CAS: 70161-20-5) was likely to be not toxic to aquatic algae at environmentally relevant concentrations and can be considered to be “not classified” as per the CLP classification criteria.
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