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EC number: 283-880-0 | CAS number: 84775-50-8 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Coriandrum sativum, Umbelliferae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Basic data given, but considered sufficiently reliable for the purpose of hazard assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Coriander, ext.
- EC Number:
- 283-880-0
- EC Name:
- Coriander, ext.
- Cas Number:
- 84775-50-8
- Molecular formula:
- Not applicable (UVCB)
- IUPAC Name:
- Essential oil of Coriandrum sativum L. (Apiaceae) obtained from seeds of coriander by steam distillation
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source: Research Institute for Fragrance Materials, Inc.
- Physical state: Clear, colorless liquid
- Date of receipt: 05 May 1971
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-300 g
- Fasting period before study: Overnight
- Housing: Animals were individually housed.
- Diet: Commercial diets, ad libitum
- Water, ad libitum
- Fasted overnight
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- Test substance was prepared as 50% (w/v or v/v) solutions or suspensions in corn oil.
Doses in mL/kg were converted into mg/kg bw from the density of the test item of 0.8687.
Initially, 2 rats were given a single dose of 5 mL/kg equivalent to 4344 mg/kg bw, by gastric intubation. Following the dosing, the toxic signs and mortality were recorded. If no deaths occurred, 8 additional rats were given the same dose via the same route.
If 1 or 2 animals died within 48 hours in the first pair of animals or if more than 2 of the total of 10 rats died within the 14-day observation period, the LD50 value was determined using 6 groups of rats (5 rats/group) by giving graded dosage levels of the test compound via the same route. - Doses:
- Primary screening test: Single dose of 5 mL/kg equivalent to 4344 mg/kg bw
Main test: Dose was 1.0 to 6.81 mL/kg equivalent to 868,7 mg/kg bw to 5916 mg/kg bw - No. of animals per sex per dose:
- 2 rats for the screening test, then 6 groups of rats (5 rats/group) for the main test
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Following the dosing, the toxic signs and mortality were recorded at one and four hours and once daily thereafter for a total of 14 days.
- Necropsy of survivors performed: Yes; gross necropsy was performed on any animal that died during the study and on survivors which were killed by cervical dislocation at termination. - Statistics:
- LD50 was calculated according to Horn's method (Horn, 1956).
Results and discussion
- Preliminary study:
- Mortality was observed in 1/2 animals in the primary screening test at 4344 mg/kg bw as well as bloody crust eyes and nose, ataxia, depression, hypopnea, lacrimation and salivation. In addition, darkened lungs, distended gastrointestinal tract and hemorrhagic lung occurred in rat that died during the screening test.
Therefore, the LD50 value was determined using 6 groups of rats (5 rats/group) by giving graded dosage levels of the test compound via the same route.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 588 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: confidence limits: 2154 to 5334 mg/kg bw
- Mortality:
- No mortality was reported in the main test.
- Clinical signs:
- other: other: No clinical signs were reported in the main test.
- Gross pathology:
- Hemorrhagic lung appeared to occur in rats killed at termination.
In addition, pale liver and kidney were observed in a few of the rats. - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the test conditions, the oral LD50 for Coriander is 3588 mg/kg bw (confidence limits: 2154 to 5334 mg/kg bw) in rats, therefore it is not classified according to Regulation (EC) No. 1272/2008 (CLP).
- Executive summary:
In an acute oral toxicity study, 2 rats were given a single dose of 5 mL/kg equivalent to 4344 mg/kg bw of test item by gastric intubation. Following the dosing, the toxic signs and mortality were recorded. As 1 animal died within 48 hours in the first pair of animals, the LD50 value was determined using 6 groups of rats (5 rats/group) by giving graded dosage levels (1.0 to 6.81 mL/kg equivalent to 868,7 mg/kg bw to 5916 mg/kg bw) of the test compound via the same route. Animals were then observed for mortality and clinical signs for 14 days and were all sacrificed for macroscopic examination.
Mortality was observed in 1/2 animals in the primary screening test at 4344 mg/kg bw as well as bloody crust eyes and nose, ataxia, depression, hypopnea, lacrimation and salivation. In addition, darkened lungs, distended gastrointestinal tract and hemorrhagic lung occurred in rat that died during the screening test. Therefore, the LD50 value was determined using 6 groups of rats (5 rats/group) by giving graded dosage levels of the test compound via the same route. No mortality and clinical signs were reported and hemorrhagic lung and some pale liver and kidney were observed at the necropsy. In this study, the oral LD50 of test item was 3588 mg/kg bw (C.I.2154-5916 mg/kg) in rats.
Under the test conditions, the oral LD50 for Coriander is 3588 mg/kg bw (confidence limits: 2154 to 5916 mg/kg) in rats, therefore it is not classified according to Regulation (EC) No. 1272/2008 (CLP).
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