Registration Dossier
Registration Dossier
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EC number: 209-294-7 | CAS number: 565-80-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
- Principles of method if other than guideline:
- In a dermal irritation test in Guinea Pigs the test substance was applied, undiluted, at a dose level of 0.5 mL to the depilated abdomens under occlusive conditions for 24 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,4-dimethylpentan-3-one
- EC Number:
- 209-294-7
- EC Name:
- 2,4-dimethylpentan-3-one
- Cas Number:
- 565-80-0
- Molecular formula:
- C7H14O
- IUPAC Name:
- 2,4-dimethylpentan-3-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in report): 2,4-Dimethylpentanon-3 / Diisopropyl keton
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test substance (as cited in report): 2,4-Dimethyl-3-pentanone
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Remarks:
- Crl:(HA)BP
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: 347- 396 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: depilated
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 14 days
- Number of animals:
- 5
- Details on study design:
- TEST SITE
- Area of exposure: abdomens
- Type of wrap if used: occlusive wrap
OBSERVATION TIME POINTS
- 24 hours, 48 hours, 14 days
SCORING SYSTEM:
- Method of calculation: Slight, Moderate, Strong, Severe
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours after the end of the exposure to the test material
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48 h
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test substance caused slight erythema in 5/5 animals when applied to the depilated abdomens of the Guinea pigs at a dose of 0.5 mL for 24 hours under occlusive conditions. All treated animals appeared normal by 24 hours after the end of the exposure to the test material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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