Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of Ethylbenzene (100-41-4) in rabbit.
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
IFA GESTIS, GESTIS SUBSTANCE Database, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as metioned below
Principles of method if other than guideline:
Acute Dermal Toxicity Study of Ethylbenzene (100-41-4) in Rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethylbenzene
EC Number:
202-849-4
EC Name:
Ethylbenzene
Cas Number:
100-41-4
Molecular formula:
C8H10
IUPAC Name:
Ethylbenzene
Details on test material:
Name - Ethylbenzene
InChI - 1S/C8H10/c1-2-8-6-4-3-5-7-8/h3-7H,2H2,1H3
Smiles - CCc1ccccc1
- Molecular formula (if other than submission substance):C8H10
- Molecular weight (if other than submission substance):106.167 g/mole
- Substance type:Organic
- Physical state:Colorless liquid
Specific details on test material used for the study:
Name - Ethylbenzene
InChI - 1S/C8H10/c1-2-8-6-4-3-5-7-8/h3-7H,2H2,1H3
Smiles - CCc1ccccc1
- Molecular formula (if other than submission substance):C8H10
- Molecular weight (if other than submission substance):106.167 g/mole
- Substance type:Organic
- Physical state:Colorless liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
not specified
Duration of exposure:
24 h
Doses:
15400 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
15 400 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed at 15400 mg/kg bw.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be 15400 mg/kg bw, when rabbits were treated with Ethylbenzene (100-41-4) occlusively for 24 h exposure to the skin.
Executive summary:

In an acute dermal toxicity study,rabbits were treated with Ethylbenzene (100-41-4) at the concentration of 15400mg/kg bw to the covered skin. 50% mortality was observed at 15400 mg/kg bw for exposure of 24 h. Therefore,LD50 was considered to be 15400 mg/kg bw, when rabbits were treated with Ethylbenzene occlusively for 24 h exposure to the skin.