Registration Dossier
Registration Dossier
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EC number: 205-502-5 | CAS number: 141-79-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- Pre-guideline study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylpent-3-en-2-one
- EC Number:
- 205-502-5
- EC Name:
- 4-methylpent-3-en-2-one
- Cas Number:
- 141-79-7
- Molecular formula:
- C6H10O
- IUPAC Name:
- 4-methylpent-3-en-2-one
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 70-150g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass chamber
- Exposure chamber volume: no data
- Method of holding animals in test chamber: no data
- Source and rate of air: 6 l/min
- Method of conditioning air: no data
- System of generating vapours: the compound was introduced by means of a syringe oparating at a constant rate. A heating coil was used to vaporize the undiluted liquid.
- Temperature, humidity, pressure in air chamber: no data - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 450, 900, 1800 and 3600 ppm
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1 130 ppm
- 95% CL:
- 950 - 1 345
- Exp. duration:
- 4 h
- Remarks on result:
- other: 4.53 mg/l
- Mortality:
- 450 ppm, no death
900 ppm, 1 death
1800 ppm, 6 deaths occuring within 24 hours
3600 ppm, 6 deaths during or shorthly after exposure - Clinical signs:
- other: 450 and 900 ppm, mild eye irritation 1800 ppm, moderate eye irritation and marked vasodilatation. 3600 ppm, severe disconfort and pulmonary diffculty, most rats became comatose after 2 hours
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information category 3 Criteria used for interpretation of results: other: Regulation (EC) No 1272/2008
- Executive summary:
Hine et al. (1960) determined the 4-hr LC50 in rats to be 1130 ppm.
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