Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 214-490-0 | CAS number: 1135-24-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The purpose of this study was to investigate the theoretical degradation by conversion to CO2 in 24 days, employing a mixed inoculum obtained from sludge.
- GLP compliance:
- no
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- activated sludge, adapted
- Details on inoculum:
- A serum-bottle variation of the Hungate technique for growing anaerobic bacteria was adapted from Miller and Wolin. Defined medium was inoculated with 10% (vol/vol) seed from a laboratory anaerobic digester fed primary settled sewage sludge on a 15-day detention time. Serum bottles (250-ml) were flushed (500 ml/min) with oxygen-free gas for 20 min before the inoculated medium was added. These cultures were incubated in the dark at 35°C.
- Duration of test (contact time):
- 24 d
- Initial conc.:
- 300 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 86
- Sampling time:
- 24 d
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- other: This testing does not allow to conclude on rapid degradability in the regulatory meaning of the term.
- Conclusions:
- Ferulic acid, present at 300 ppm in water, reached 86% of its theoretical degradation by conversion to CO2 in 24 days, employing a mixed inoculum obtained from sludge.
Although this testing suggests that Ferulic acid easily degrades in anaerobic conditions, this testing does not allow to conclude on rapid degradability of the substance in the regulatory meaning of the term. - Executive summary:
Ferulic acid is expected to easily degrade in water under anaerobic conditions. However, this testing does not allow to conclude on rapid degradability of the substance in the regulatory meaning of the term.
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The purpose of this study was to investigate the theoretical degradation by CO2 production in 9 days, employing a mixed inoculum obtained from sludge, in which the medium had been acclimated with ferulic acid for 540 days.
- GLP compliance:
- no
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- activated sludge, adapted
- Initial conc.:
- 300 mg/L
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 98
- Sampling time:
- 9 d
- Remarks on result:
- other:
- Remarks:
- employing a mixed inoculum obtained from sludge(2), in which the medium had been acclimated with ferulic acid for 540 days
- Details on results:
- Total gas produced reached 98% after 9 days i.e. 1.53 mmol actual measured for 1.55 Theoretical with medium enrich with ferulic acid.
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- other: This testing does not allow to conclude on rapid degradability in the regulatory meaning of the term.
- Conclusions:
- Ferulic acid, present at 300 ppm in water, reached 98% of its theoretical degradation by CO2 production in 9 days, employing a mixed inoculum obtained from sludge, in which the medium had been acclimated with ferulic acid for 540 days. Although this testing suggests that Ferulic acid easily degrades in anaerobic conditions, this testing does not allow to conclude on rapid degradability of the substance in the regulatory meaning of the term.
- Executive summary:
Ferulic acid, present at 300 ppm in water, reached 98% of its theoretical degradation by CO2 production in 9 days, employing a mixed inoculum obtained from sludge, in which the medium had been acclimated with ferulic acid for 540 days. Degradation products detected were p-hydroxycinnamic acid, cinnamic acid, and phenylpropionic acid.
Therefore, Ferulic acid is expected to easily degrade in water under anaerobic conditions. However, this testing does not allow to conclude on rapid degradability in the regulatory meaning of the term.
Referenceopen allclose all
Description of key information
Two studies carried out under anaerobic conditions refer to the degradation of Ferulic acid in water.
In the first study, Ferulic acid, present at 300 ppm in water reached 86% of its theoretical degradation by conversion to CO2 in 24 days, employing a mixed inoculum obtained from sludge.
In the second study, Ferulic acid present at 300 ppm in water, reached 98% of its theoretical degradation by CO2 production in 9 days, employing a mixed inoculum obtained from sludge, in which the medium had been acclimated with ferulic acid for 540 days.
Although these suggest that Ferulic acid easily degrades in these conditions, those two testings do not allow to conclude on rapid degradability in the regulatory meaning of the term. Indeed, data regarding anaerobic degradation can not be used in relation to deciding whether a substance should be regarded as rapidly degradable, because the aquatic environment is generally regarded as the aerobic compartment where the aquatic organisms, such as those employed for aquatic hazard classification, live (A9.4.2.4.11).
Therefore, although Ferulic acid is expected to easily degrade in these conditions (under anaerobic conditions), it shall be considered as not rapidly degradable.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.