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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
HSDB for the CAS: 614-45-9
Author:
U S National Library of Medicine
Year:
2002
Bibliographic source:
Hazardous Substance Databank (HSDB), U S National Library of Medicine, last updated 2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of t –butyl perbenzoate in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
tert-butyl perbenzoate
EC Number:
210-382-2
EC Name:
tert-butyl perbenzoate
Cas Number:
614-45-9
Molecular formula:
C11H14O3
IUPAC Name:
tert-butyl benzenecarboperoxoate
Test material form:
liquid
Details on test material:
Name of the test chemical:t –butyl perbenzoate
Molecular Formula:C11H14O3
Molecular Weight: 194.2286 g/mol
Substance Type: Organic
Physical State: Liquid
Specific details on test material used for the study:
Name of the test chemical:t –butyl perbenzoate
Molecular Formula:C11H14O3
Molecular Weight: 194.2286 g/mol
Substance Type: Organic
Physical State: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
other: albino
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
other: 50% dimethyl phthtalate
Controls:
not specified
Amount / concentration applied:
2drops of solution in 50% dimethyl phthtalate
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
TEST SITE
- Area of exposure: eyes

SCORING SYSTEM: Graded on a scale of 0-7
0 being not irritating and 7 being irritating

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Score:
1
Max. score:
7
Reversibility:
not specified
Remarks on result:
probability of weak irritation
Irritant / corrosive response data:
t- butyl perbenzoate was graded 1 on scale of 0 to 7.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
t- butyl perbenzoate was graded 1 on scale of 0 to 7.
Hence, t-butyl perbenzoate can be considered not irritating to rabbit eyes.
Executive summary:

The ocular irritation potential of t- butyl perbenzoatewas assessed in rabbits.

 2 drops oft- butyl perbenzoate solution in 50% dimethyl phthtalate was instilled into rabbit eyes (number not specified).The rabbits were observed for signs of irritation (duration not specified) and graded on a scale of 0-7. Slight irritation was observed.

t- butyl perbenzoate was graded1 on scale of 0 to 7.

Hence, t-butyl perbenzoate can be considered not irritating to rabbit eyes.