Registration Dossier
Registration Dossier
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EC number: 690-928-8 | CAS number: 39992-90-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch: 703709
Purity: 100 %
CoA: 2017-02-15 - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. 1.81
- Temp.:
- 20 °C
- pH:
- ca. 7
- Details on results:
- Two measurements made under identical conditions and usng the same set of reference items fall within a range of +/- 0.1 log units. The requirements of OECD guideline 117 concerning the quality critria are fulfilled.
- Conclusions:
- The log Po/w of IPDI-Uron is 1.81.
- Executive summary:
The aim of this study was the determination of the n-octanol/water partition coefficient of IPDI-Uron by HPLC method according to EC method A.8 and OECD guideline 117.
The analysis was performed in an analytical column packed with a solid phase containing long hydrocarbon chains chemically bound onto silica (Luna 5µ C18(2) 100A; 250 x 3.0 mm).
A mixture of 60 % methanol and 40 % ultra-pure grade water was used as a mobile phase and the column temperature was 20 °C +/- 1°C
As the determination of the test item leads to three signals the weighted average log Po/w was calculated using the relative area and the Po/w of each single signal.
Reference
Description of key information
The log Po/w of IPDI-Uron is 1.81.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.81
- at the temperature of:
- 20 °C
Additional information
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