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EC number: 234-054-3 | CAS number: 10519-11-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 October 2000 - 26 October 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: The stock solution was analysed at 0 hours, the control was analysed at 0 and 48 hours, and test concentrations were analysed at 0, 24 and 48 hours
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: A stock solution was prepared to give the desired series of test concentrations. 105.9 mg of the test substance were added to 2 litres of dilution water, treated with an ultra turrax for 60 seconds and afterwards stirred for 24 h an a magnetic stirrer.
- Controls: Dilution water
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): Finally undissolved particles of the test substance were removed by filtration. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Age of parental stock: Parthenogenetic females of synchronised age
- Feeding during test: None
ACCLIMATION
- Acclimation conditions (same as test or not): Yes
- Type and amount of food: Unicellular green algae (Scenedesmus subspicatus CHODAT)
- Feeding frequency: ad libitum
METHOD FOR PREPARATION AND COLLECTION OF EARLY INSTARS OR OTHER LIFE STAGES: The neonates were separated from their parent Daphnia by filtration prior to the acute test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 271.3 mg/1 CaCO3
- Test temperature:
- 19.9 - 20.2°C
- pH:
- 7.7 - 7.8
- Dissolved oxygen:
- 8.2 - 8.8 mg/L
- Nominal and measured concentrations:
- Nominal concentrations 1.25, 2.5, 5, 10, 20 and 36 mg/L
Initial measured concentrations 1.2, 2.4, 5.6, 9.8, 21 and 35 mg/L
Measured concentrations at 48 hours 1.3, 2.6, 7, 8.4, 23.8 and 37.8* mg/L
* Measured after 24 hours of exposure because of early 100% immobilisation rates of the daphnids - Details on test conditions:
- TEST SYSTEM
- Test vessel: Karlsruher Flaschen
- Type: closed
- Material, size, headspace, fill volume: 250 to 300 mL test medium per vessel
- Aeration: None
- No. of organisms per vessel: 10 neonates per vessel
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: M4 medium
- Intervals of water quality measurement: Temperature, pH and dissolved oxygen measured at 0 and 48 hours
OTHER TEST CONDITIONS
- Photoperiod: 16h light: 8h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Substance-induced alteration of the normal mobility behaviour and the loss of locomotory actions of the neonates were observed at 24 and 48 hours. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- other: EC0/EC100
- Effect conc.:
- 7.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 2.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Remarks:
- Calculated (corresponding to the analytical recovery rate of the highest test concentration) as the concentration to be measured was below the quantitation limit of the TOC method (2 mg/L)
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 22.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- other: EC0/EC100
- Effect conc.:
- 13.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- 36 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Measured concentrations: 97.2 — 112% of nominal values at 0 hours, 84 — 140% of nominal values at 48 hours
- Mortality of control: No mortalities occurred throughout the duration of the study - Reported statistics and error estimates:
- In those cases where the slope of the concentration/percentage response curve is too steep to permit calculation of the EC50, this value is estimated graphically.
- Validity criteria fulfilled:
- yes
- Remarks:
- Immobilisation in the control was < 10% by the end of the test, the dissolved oxygen concentration was >3 mg/L throughout the exposure period, and the concentration of the test substance was within 80% of the initial concentration throughout the study.
- Conclusions:
- The 48 hour EC0/EC100 was determined to be 7.5 mg/L for Daphnia magna exposed to the test item.
- Executive summary:
Short-term toxicity of the test item to Daphnia magna was evaluation in a 48 -hour static test. Daphnia were exposed to nominal test item concentrations of 1.25, 2.5, 5, 10, 20 and 36 mg/L in a closed system, alongisde a dilution water control. Measured test concentrations were 97.2 to 112% of nominal values at 0 hours and 84 to 140% of nominal values at 48 hours based on TOC analysis. The 48-hour EC0/EC100 was determined to be 7.5 mg/L, based on geometric mean measured concentrations. The study was GLP-compliant and was conducted according to EU Method C.2. The study is reliable with restrictions (Klimisch 2) as there were some limitations in the reporting of methods and results.
Reference
Description of key information
The 48 hour EC50 was determined to be 7.5 mg/L for Daphnia magna exposed to the test item.The 48-hour EC0/EC100 was determined to be 7.5 mg/L, based on geometric mean measured concentrations.
The 48-hour EC0/EC100 was determined to be 7.5 mg/L, based on geometric mean measured conce
trations.
ons.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 7.5 mg/L
Additional information
Short-term toxicity of the test item to Daphnia magna was evaluated in a 48 -hour static test (2000). Daphnia were exposed to nominal test item concentrations of 1.25, 2.5, 5, 10, 20 and 36 mg/L in a closed system, alongisde a dilution water control. Measured test concentrations were 97.2 to 112% of nominal values at 0 hours and 84 to 140% of nominal values at 48 hours based on TOC analysis. The 48-hour EC0/EC100 was determined to be 7.5 mg/L, based on geometric mean measured concentrations. The study was GLP-compliant and was conducted according to EU Method C.2. The study is reliable with restrictions (Klimisch 2) as there were some limitations in the reporting of methods and results.
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