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Diss Factsheets
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EC number: 204-420-7 | CAS number: 120-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth et.al
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs
- Author:
- D.L.J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 12, Issues 7–8, December 1974, Page 915
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary skin irritation study was performed on rabbits for the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Indole
- EC Number:
- 204-420-7
- EC Name:
- Indole
- Cas Number:
- 120-72-9
- Molecular formula:
- C8H7N
- IUPAC Name:
- 1H-indole
- Test material form:
- solid
- Details on test material:
- Name: Indole
IUPAC Name: 1H-Indole
Molecular Formula: C8H7N
Molecular Weight: 117.15 g/mol
SMILES: c1ccc2[nH]ccc2c1
Substance Type: Organic
Physical State: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml of undiluted sampl
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24, 72 hours
- Number of animals:
- five albino rabbits
- Details on study design:
- TEST SITE
- Area of exposure: clipped skin of uncovered rabbit belly
- % coverage:
- Type of wrap if used: not used
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
OBSERVATION TIME POINTS
(indicate if minutes, hours or days) :
SCORING SYSTEM:
- Method of calculation: Reactions observed were graded on 10-grade ordinal series and was based upon the severest reaction on clipped uncovered rabbit belly. On a scale of 1-10, Grade 1 indicated no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicated necrosis when undiluted and Grade 10 indicated necrosis from a 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test chemical was reported as not irritating to the uncovered rabbit belly with a score of 1.
Any other information on results incl. tables
Primary skin irritation study:
CAS |
Grades |
120-72-9 |
1 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The test chemical was reported as not irritating to the uncovered rabbit belly with a score of 1.
- Executive summary:
Primary skin irritation study was performed on rabbits for the test chemical. 0.01 ml of undiluted test chemical was applied to the clipped skin of 5 albino rabbits for 24 hours. The application site was left uncovered. Reactions observed were graded on 10-grade ordinal series and was based upon the severest reaction on clipped uncovered rabbit belly. On a scale of 1-10, Grade 1 indicated no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicated necrosis when undiluted and Grade 10 indicated necrosis from a 0.01% solution.The test chemical was reported as not irritating to the uncovered rabbit belly with a score of 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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