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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VIII
Author:
Charles P . Carpenter, Carrol S. Weil and Henry F. Smyth, JR.
Year:
1974
Bibliographic source:
Toxicology and Applied Pharmacology 28,313-319 (1974)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of 4-morpholinecarbaldehyde (4394-85-8) was performed in rabbits.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Reference substance name:
morpholine-4-carbaldehyde
Cas Number:
4394-85-8
Molecular formula:
C5H9NO2
IUPAC Name:
morpholine-4-carbaldehyde
Details on test material:
- Name of test material (IUPAC name): 4-morpholinecarbaldehyde
- Common name: N-Formylmorpholin
- Molecular formula: C5H9NO2
- Molecular weight: 115.131 g/mol
- Smiles notation: N1(CCOCC1)C=O
- InChl: 1S/C5H9NO2/c7-5-6-1-3-8-4-2-6/h5H,1-4H2
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):4-Formylmorpholine
- Molecular formula :C5H9NO2
- Molecular weight :115.131 g/mol
- Substance type:organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
16000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 16 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed in treated rabbits at 16000 mg/kg bw.
Mortality:
No mortality was observed in treated rabbits at 16000 mg/kg bw.
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 value was considered to be >16000 mg/kg bw,when rabbits were treated with 4-morpholinecarbaldehyde (4394-85-8) by dermal application.
Executive summary:

In acute dermal toxicity study, rabbits were treated with 4-morpholinecarbaldehyde (4394-85-8) in the concentration of 16000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 16000 mg/kg bw.Therefore, LD50 value was considered to be >16000 mg/kg bw,when rabbits were treated with 4-morpholinecarbaldehyde (4394-85-8)by dermal application.