Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 426-840-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 05, 1996 - March 17, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted March 30, 1989
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- adopted July 27, 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- EEC Pubilcation No. L383A, december 1992
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.84
- Remarks on result:
- other: Isomer I
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.47
- Remarks on result:
- other: Isomer II
- Details on results:
- The partition coefficient log Pow for the test article was then calculated from its concentrations in the n-octanol phase and in the aqueous phase according to equation below.
Log Pow = Log 10 (equilibrium c n-octanol / equilibrium c water)
The partition coefficient was determined to be
log Pow = - 2.84 for Isomer I
log Pow = - 2.47 for Isomer II - Conclusions:
- The partition coefficient for the test article SCARLET RN 1165 was determined to be
log Pow = - 2.84 for Isomer I
log Pow = - 2.47 for Isomer II - Executive summary:
In principle, the log Pow can be determined by the flask shaking method (log Pow between -2 and 4, OECD guideline no. 107) or alternatively, by the HPLC-method as described in OECD guideline no. 117 (log Pow between 0 and 6). Limitations and gaps of both methods are described in the guidelines.
In a pre-test, the log Pow of the test article was estimated from its solubility in water and in n-octanol to be < - 2. This value is out of the range of both methods. Therefore the flask shaking method was modified in that the log Pow was determined from the concentrations of the test article in saturated solutions in water and octanol.
The partition coefficient log Pow for the test article was then calculated from its concentrations in the n-octanol phase and in the aqueous phase according to equation below.
Log Pow = Log 10 (equilibrium c n-octanol / equilibrium c water)
The partition coefficient for the test article SCARLET RN 1165 was determined to be
log Pow = - 2.84 for Isomer I
log Pow = - 2.47 for Isomer II
Reference
The partition coefficient log Pow for the test article was then calculated from its concentrations in the n-octanol phase and in the aqueous phase according to equation below.
Log Pow = Log 10 (equilibrium c n-octanol / equilibrium c water)
In a pre-test the log Pow was estimated from the individual solubilities of the test article in water and in n-octanol to be =< -2. This is lower than the limit of the useful range of the flask shaking method. Therefore also in the main test the log Pow was determined from the individual solubilities. During the main study, saturated solutions of the test article in water and n-octanol were prepared in duplicate. After equilibration the concentration of the test article was determined in every phase by HPLC.
The partition coefficient was determined to be
log Pow = - 2.84 for Isomer I
log Pow = - 2.47 for Isomer II
Results of the log Pow test
Isomer I
Sample | Solvent | Concentration* | Mean conc. | log Pow |
1 | water | 96907 | 92801 | -2.84 |
2 | water | 88695 | ||
3 | n-octanol | 128.3 | 132.7 | |
4 | n-octanol | 137.0 |
Isomer II
Sample | Solvent | Concentration* | Mean conc. | log Pow |
1 | water | 102676 | 98641 | -2.47 |
2 | water | 94606 | ||
3 | n-octanol | 333.9 | 331.5 | |
4 | n-octanol | 329.0 |
* Relative concentrations were calculated under the hypothesis that the test article consists of 100 % of each isomer.
Description of key information
The partition coefficient for the test article SCARLET RN 1165 was determined to be
log Pow = - 2.84 for Isomer I
log Pow = - 2.47 for Isomer II
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.84
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.