Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-440-1 | CAS number: 2437-25-4
Endpoint summary
Administrative data
Description of key information
Irrittating to skin (GHS Cat.2)
Non-irritating to eyes
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In a GLP compliant OECD TG 404 study, Dodecanenitrile was applied semi-occlusively for 4 hours to the shaved skin of three New Zealand White Rabbits. Well-defined up to moderate to severe erythema and slight edema were observed in all three animals. All signs of irritation were fully reversible between day 7 and day 14 post application. Average scores for erythema were 3.0, 3.0 and 2.67 (for 24h, 48h and 72h) in all animals. Scores for oedema were 4.0, 1.7 and 1.7 for the same time points. Based on these study results, the test material Dodecannitrile is considered to be irritating to skin. (GHS Cat.2).
Dodecanenitrile was evaluated for eye irritation in New-Zealand rabbits according to OECD 405 and EU 84/449/EEC B.5 guidelines. 0.1 mL of undiluted test material was instilled in one eye of each animal. The eyes were flushed after 24 hours. Results: No irritation was observed.
Effects on skin irritation/corrosion: irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Available information indicates that alkylnitriles are irritating to the skin, but not irritating to the eyes.
Dermal irritation:
An adequate guideline study with Dodecanenitrile has shown the substance to be irritating to skin.
A similar study performed with Tallownitrile resulted to similar results showing that alsoTallownitrile is considered to be irritating to skin. (GHS Cat.2)
Other available dermal irritation studies other alkylnitriles also indicated dermal irritation but the actual scoring in those studies was not sufficient to reach a Cat.2 classification.
In view of the collective data on dermal irritation on the various alkylnitriles, the weight of evidence indicates that it is considered prudent to classify the alkylnitriles collectively as irritating to skin.
Eye irritation:
Although irritating to the skin, none of the in vivo eye irritation studies performed on the various alkyl nitriles, including Dodecanenitrile, indicated a concern for eye irritation.
Respiratory irritation:
There is no information on possible respiratory irritation. Based on the available information on skin and eye irritation, alkylnitriles are not expected to pose a great concern in this respect. Moreover, based on the very low vapour pressure and water solubility, respiratory irritation is not likely to occur.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
