Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation in water

Biodegradability of 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid (CAS no. 6334 -97 -0) is predicted using QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 0.57% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid

was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid (CAS No. 6334 -97 -0). If released in to the environment, 16.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid in sediment is estimated to be 337.5 days (8100  hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.122%), indicates that 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 6334 -97 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid in soil is estimated to be 75 days (900 hrs). Based on this half-life value of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Various predicted data for the target compound 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 6334-97-0) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid(CAS No. 6334-97-0) was estimated.Test substance undergoes 0.57% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound7-acetamido-4-hydroxynaphthalene-2-sulfonic acid(CAS No. 6334-97-0) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, HSDB, 2017 and EnviChem, 2014) for the read across chemical 2, 4, 4’ – Trichloro – 2’-hydroxy diphenyl ether (CAS no. 3380-34-5), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2, 4, 4’ – Trichloro – 2’-hydroxy diphenyl ether. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) under aerobic conditions. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance2, 4, 4’ – Trichloro – 2’-hydroxy diphenyl etherwas determined to be 0 and 1% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 2, 4, 4’ – Trichloro – 2’-hydroxy diphenyl ether is considered to be not readily biodegradable in nature.

 

Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 2, 4 – Dibromophenol (CAS no. 615-58-7) (J-CHECK and HSDB, 2017). The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)) under aerobic conditions. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance 2, 4 – Dibromophenol was determined to be0 and 2% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation,2, 4 – Dibromophenol is considered to be not readily biodegradable in nature.

 

For the read across chemical (2-hydroxy-4-(octyloxy)phenyl)(phenyl)methanone (CAS no. 1843-05-6), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across chemical (2-hydroxy-4-(octyloxy)phenyl)(phenyl)methanone (HSDB, 2017). The study was performed according to OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test) under aerobic conditions. Non-adapted activated sludge was used as a test inoculum during the study. Initial test substance conc. used in the study were 10.7 and 20.2 mg/l, respectively. The percentage degradation of substance (2 -hydroxy-4 -(octyloxy)phenyl)(phenyl) methanone was determined to be 5 -6% by using CO2 evolution parameter after 28 days. Thus, based on percentage degradation, (2 -hydroxy-4 -(octyloxy)phenyl)(phenyl)methanone is considered to be not readily biodegradable in nature.

 

In a supporting weight of evidence study from authoritative database (SRC PhysProp Database, 2017) and secondary source (HPVIS, 2017) for the read across chemical 2,4-bis(1,1-dimethylethyl)phenol (CAS no. 96-76-4),biodegradation experiment was conducted using method "BOD test for insoluble substances" for 28 days for evaluating the percentage biodegradability of read across substance 2,4 -bis(1,1 -dimethylethyl)phenol under aerobic conditions. Non-adapted activated sludge was used as a test inoculum for the study. Initial test chemical concentration used for the study was 34.5 mg/l. The percentage degradation of substance 2,4 -bis(1,1 -dimethylethyl)phenol was determined to be 2% by BOD parameter in 28 days.  Thus, based on percentage degradation, 2,4 -bis(1,1 -dimethylethyl)phenol is considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid(from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, HSDB, EnviChem, SRC PhysProp Database and secondary source HPVIS), it can be concluded that the test substance 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid can be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid (CAS No. 6334 -97 -0). If released in to the environment, 16.7% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid in sediment is estimated to be 337.5 days (8100  hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.122%), indicates that 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 6334 -97 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid in soil is estimated to be 75 days (900 hrs). Based on this half-life value of 7 -acetamido-4 -hydroxynaphthalene-2 -sulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance 7-acetamido-4-hydroxynaphthalene-2-sulfonic acid can be considered to be not readily biodegradable in nature.