Registration Dossier
Registration Dossier
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EC number: 430-740-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
LD50 > 2000 mg/kg b.w. The substance is not toxic for oral exposure
LD50 > 2000 mg/kg b.w. The substance is not toxic for dermal exposure
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Crl:CD(SD)BR - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No clinical signs occurred in the treated animals. Body weight growth of the treated animals was normal during the observationperiod. - Gross pathology:
- Effects on organs:
At the final killing no appreciable macroscopic findings were evident in any treated rat. - Interpretation of results:
- other: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Test conducted according to internationally accepted testing guidelines.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Test conducted according to internationally accepted testing guidelines.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Crl:CD(SD)BR - Type of coverage:
- semiocclusive
- Duration of exposure:
- 24 h
- Control animals:
- yes, concurrent no treatment
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No clinical abnormalities were seen in any treated animal. - Gross pathology:
- Effects on organs:
No appreciable changes were evident in the treated animals of either sex at the autopsy carried out at the end of the observationperiod. - Other findings:
- Signs of toxicity (local):
No clinical abnormalities were seen in any treated animal. - Interpretation of results:
- other: not classified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Test conducted according to internationally accepted testing guidelines.
Additional information
All tests of acute toxicity shows a values above the trigger value of 2000 mg/kg b.w, therefore no classification is warranted.
Justification for classification or non-classification
No classification for acute toxicity oral is warranted under Regulation 1272/2008
No classification for acute toxicity inhalation is warranted under Regulation 1272/2008
No classification for acute toxicity dermal is warranted under Regulation 1272/2008
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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