Registration Dossier
Registration Dossier
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EC number: 944-548-7 | CAS number: -
Endpoint summary
Administrative data
Description of key information
No studies on the toxicity of insulin Aspart Ethyl Ester towards algae, invertebrates and fish were available.
The aquatic toxicity of Insulin Aspart Ethyl Ester is assumed to be similar to the source substance (S4) because of the high degree of structural similarity:
• Insulin Aspart Ethyl Ester and the source substance belong to the same chemical categories: human insulins, polypeptides and proteins
• Insulin Aspart Ethyl Ester and the source substance are composed of polypeptide containing amino acids.
Insulin Aspart Ethyl Ester is predicted to have a toxicity to algae with EC10 and EC50 of > 300 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No effects towards algae was observed during the study with Insulin Aspart Precursor (S4) and EC10 and EC50 are therefore reported as > 300 mg/L (> 258 geometric mean concentration).
Insulin Aspart Ethyl Ester is predicted to have a toxicity to invertebrates with EC10 and EC50 of > 300 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No effects were observed towards invertebrates during the study with Insulin Aspart Precursor (S4) and EC10 and EC50 are therefore reported as > 300 mg/L (> 254.8 mg/L geometric mean concentration).
Insulin Aspart Ethyl Ester is predicted to have a toxicity to fish with LC50 of > 50,1 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No mortality to fish was observed during the study with Insulin Aspart Precursor (S4) and LC50 is therefore reported as > 50,1 mg/L (geometric mean concentration).
Additional information
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