Registration Dossier
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EC number: 273-453-7 | CAS number: 68966-86-9
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14/8/2013 to 30/10/2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 5
- Temp.:
- 40 °C
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- Testing was performed at neutral pH. (without pH adjustment to the mobile phase with the test material in its non-ionised form) and a column temperature of 40°C
- Conclusions:
- The log Pow of the test material was determined to be 5.0.
- Executive summary:
The partition coefficient of the test item was determined by HPLC method according to OECD TG 117. A calibration curve was constructed from the retention time data of thiourea and six reference standard solutions. The log Pow was determined to be 5.0, and it was calculated by HPLC calibration curve.
This study is reliable without restrictions (Klimisch 1) as it followed an accepted guideline.
Reference
Table 1 Results from the partition coefficient study
Injection |
Retention time (min) |
Capacity factor (K) |
Log10K |
LogPow |
1 |
6.356 |
2.30 |
0.36 |
5.0 |
2 |
6.372 |
2.31 |
0.36 |
5.0 |
Average |
6.364 |
2.31 |
0.36 |
5.0 |
Description of key information
The log Pow of the test material was determined to be 5.0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5
- at the temperature of:
- 40 °C
Additional information
The partition coefficient of the test item was determined by HPLC method according to OECD TG 117 (2014). A calibration curve was constructed from the retention time data of thiourea and six reference standard solutions. The log Pow was determined to be 5.0, and it was calculated by HPLC calibration curve.
This study is reliable without restrictions (Klimisch 1) as although it is not GLP-compliant it followed an accepted, standard guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
