Registration Dossier
Registration Dossier
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EC number: 205-471-8 | CAS number: 141-23-1
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Specification data long held by the manufacturer. Practical handling experience has not resulted in the questioning of the accuracy of this data.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Deviations:
- yes
- Remarks:
- no solubility data taken specifically at 37 and 50 °C; no standard fat used.
- Principles of method if other than guideline:
- Solubility was assessed in various organic solvents rather than in a standard fat (triglyceride). Heating was undertaken to facilitate solubility as needed.
- GLP compliance:
- no
- Key result
- Medium:
- ethanol
- Solubility:
- 21 vol%
- Temp.:
- 22 °C
- Key result
- Medium:
- toluene
- Solubility:
- 8 vol%
- Temp.:
- 22 °C
- Key result
- Medium:
- n-butanol
- Solubility:
- 8 vol%
- Temp.:
- 22 °C
- Key result
- Medium:
- other: methyl ethyl ketone
- Solubility:
- 8 vol%
- Temp.:
- 22 °C
- Key result
- Medium:
- other: mineral spirits
- Remarks:
- odourless
- Solubility:
- 3 vol%
- Temp.:
- 22 °C
- Key result
- Medium:
- other: 2-ethoxyl ethyl alcohol
- Solubility:
- 22 vol%
- Temp.:
- 22 °C
- Test substance stable:
- not determined
- Conclusions:
- The test material was found to be 21-22% soluble in ethanol (EtOH) and 2-ethoxyl ethyl alcohol. It was 8% soluble in toluene, butyl alcohol and methyl ethyl ketone (MEK), and minimally soluble (3%)in odourless mineral spirits.
Reference
Description of key information
Maximal solubility was 22% in 2-ethoxyl ethyl alcohol; lower for other organic solvents.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 2.2 g/L
Additional information
The test material was found to be 21-22% soluble in ethanol (EtOH) and 2-ethoxyl ethyl alcohol. It was 8% soluble in toluene, butyl alcohol and methyl ethyl ketone (MEK), and minimally soluble (3%) in odourless mineral spirits. The maximal solubility is in
2-ethoxyl ethyl alcohol (22%) or 22 g/100 ml or 2.2 g/L. The substance was not tested in standard fat (triglyceride).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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