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EC number: 210-351-3 | CAS number: 613-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- o-phenylenediacetonitrile
- EC Number:
- 210-351-3
- EC Name:
- o-phenylenediacetonitrile
- Cas Number:
- 613-73-0
- Molecular formula:
- C10H8N2
- IUPAC Name:
- 2-[2-(cyanomethyl)phenyl]acetonitrile
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 642 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 390 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Harmful if swallowed
- Executive summary:
Acute oral toxicity of lr2 Phenylendiacetonitril was tested in female and male Charles River
Wistar rats. The test substance was administered in doses between 800 and 200 mglkg body
weight (bw) by stomach tube.
The observation period was 14 days long.
Animals were examined for mortality, clinical signs, body weight gain and pathological
alterations of organs.
The LD50value was for male animals 642 mglkg bw and for
female animals 390 mg /kg bw.
The animals died in the most cases in the first 4 hours p.a.
The animals responded very quickly to the application of the test substance. The period of
recovery of the survival animals was finished on day 1 p.a.
Moderate to severe clinical signs were observed in all animals treated with the test substance.
The most striking findings were apathy, squatting/abdominal position, disorder of respiration in
rhythm or intensþ and tremor and clonic convulsions. A dose independent increased blood
circulation of the skin was observed in nearly all animals.
The body weight development was dose dependent retarded in the surviving animals.
The macroscopic pathological examination showed haemorrhagic gastric mucosa and
pulmonary emphysema in the animals which died in the course of testing.
The pulmonary emphysema could be seen as cause of death.
The tremor and convulsions or the increased circulation show the central action of the test
substance.
According to the criteria of Annex IV of Council Directive 93/21/EEC Commission Directive
of 2TthApril 1993 1,2 Phenylendiacetonitril is after the examination of acute oral toxicþ a
harmful substance and is to label with R 22 "Harmful if swaltowed" and the danger symbol
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