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EC number: 200-917-8 | CAS number: 75-94-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01.12.95 to 31.12.95
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- one hour exposure period due to corrosivity of test substance
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trichloro(vinyl)silane
- EC Number:
- 200-917-8
- EC Name:
- Trichloro(vinyl)silane
- Cas Number:
- 75-94-5
- Molecular formula:
- C2H3Cl3Si
- IUPAC Name:
- trichloro(vinyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: Approximately 6 weeks old when received
- Weight at study initiation: 75-100 g when received
- Fasting period before study: No data
- Housing: Individually in stainless steel cages
- Diet (e.g. ad libitum): Ad libitum, except during exposure
- Water (e.g. ad libitum): Ad libitum, except during exposure
- Acclimation period: One week
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65-78
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 5.12.95 To: 27.12.95
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: not applicable
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: PVC and plexiglass whole body chamber.
- Exposure chamber volume: 175 litres
- Method of holding animals in test chamber: Wire mesh caging
- Source and rate of air: Filtered room air at 44-45 air changes per hour.
- Method of conditioning air: HEPA and activated carbon
- Treatment of exhaust air: No data
- Temperature, humidity, pressure in air chamber: Slight negative pressure, temperature was monitored but no information in study report, humidity was controlled to influence the hydrolysis of the test substance.
TEST ATMOSPHERE
- Brief description of analytical method used: Gas chromatograph and mass spectrometer.
- Samples taken from breathing zone: no information, but probably not as animals free to move in chamber.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- four samples during each exposure
- Duration of exposure:
- 1 h
- Remarks on duration:
- Exposure period was shorter than guideline recommendation of 4 hours due to corrosive nature of test substance.
- Concentrations:
- 500, 575 665 and 832 (Mean chamber concentration). Nominal chamber concentrations (1186, 1681, 1605 and 1989, respectively) were significantly higher than the actual concentrations due to hydrolysis of the test substance.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were once per day for 14 days (twice per day for mortality). Body weights measured on Days 1, 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathological examination of all animals. - Statistics:
- The inhalation median lethal concentration (LC50), 95% fiducial limits, and approximate slope of the dose response curve were calculated using a SAS/STAT Probit method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 1 611 ppm
- 95% CL:
- >= 1 505 - <= 1 724
- Exp. duration:
- 1 h
- Remarks on result:
- other: PREFERRED VALUE - based on nominal chamber concentrations
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 631 ppm
- 95% CL:
- 589 - 689
- Exp. duration:
- 1 h
- Remarks on result:
- other: based on mean chamber concentrations.
- Mortality:
- All animals at the highest dose died. Six and three animals died at 665 ppm and 575 ppm, respectively. No animals died at the lowest dose.
- Clinical signs:
- other: Respiratory, eye and nasal effects and soiling were observed in all groups. Activity effects were also noted in animals exposed to 575, 665 and 832 ppm of the test material. Respiratory effects in all groups included labored breathing, rales and gasping.
- Body weight:
- A majority of the surviving animals gained weight by the end of the 14-day observation period. However, weight loss was noted in surviving animals exposed to 575 and 665 ppm at the end of the first week.
- Gross pathology:
- No significant test article-related gross pathological findings were noted in animals at the terminal sacrifice. Test article-related gross pathological findings noted in a majority of animals which died during the 14-day observation period included hemorrhage, congestion and/or consolidation of the lungs, discoloration and/or staining of hair, and/or staining of hair due to porphyrin pigment. Blood in the gastrointestinal tract and discoloration of extremities was noted in a majority of animals which died that were exposed to 832 ppm and a few of the animals which died that were exposed to 575 and 665 ppm of the test material.
Any other information on results incl. tables
Number of deaths at each dose level:
Sex |
Dose level - actual chamber concentrations (ppm) |
No. Deaths |
Males |
500 |
0/5 |
575 |
2/5 |
|
665 |
4/5 |
|
832 |
5/5 |
|
Females |
500 |
0/5 |
575 |
2/5 |
|
665 |
4/5 |
|
832 |
5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a good quality acute inhalation study conducted according to OECD 403 and GLP (reliability score 1), with the exception that the exposure period was 1-hour due to the corrosive nature of the test substance, the LC50 for trichloro(vinyl)silane was 1611 ppm in rats.
- Executive summary:
In a good quality acute inhalation study conducted according to OECD test guideline 403 and GLP, Sprague-Dawley rats were exposed to trichloro(vinyl)silane at mean chamber concentrations of 500, 575, 665 and 832 ppm (nominal chamber concentrations 1186, 1681, 1605 and 1989, respectively), for one hour (reduced exposure duration due to corrosive nature of test substance). All animals exposed to the highest concentration died. Six and three animals died at 665 ppm and 575 ppm, respectively. No animals died at the lowest concentration. Respiratory (labored breathing, rales and gasping), eye (corneal opacities, alopecia around eyes, drainage/discharge from eyes, dried material eyes and closed or partially closed eyes) and nasal (dried material/crustation on and around the nose) effects and soiling were observed in all groups. Hypoactivity, ataxia and lethargy were also noted in animals exposed to 575, 665 and 832 ppm of the test material. There were no significant test article-related clinical signs noted at the end of the 14 day observation period. The majority of the surviving animals gained weight by the end of the 14-day observation period. However, weight loss was noted in surviving animals exposed to 575 and 665 ppm at the end of the first week. No significant test article-related gross pathological findings were noted in animals at the terminal sacrifice. Test article-related related gross pathological findings noted in a majority of animals which died during the 14-day observation period included hemorrhage, congestion and/or consolidation of the lungs, discoloration and/or staining of hair, and/or staining of hair due to porphyrin pigment. Blood in the gastrointestinal tract and discoloration of extremities was noted in a majority of animals which died that were exposed to 832 ppm and a few of the animals which died that were exposed to 575 and 665 ppm of the test material.
In the original study the one-hour LC50 value was calculated to be 631 ppm based on actual chamber concentrations. However, the LC50 based on mean chamber concentrations ignores the contribution from hydrolysis products. Therefore, in an amendment to this study Spearman-Karber analysis was conducted using nominal chamber concentrations and mortality data to produce an LC50 value of 1611 ppm, with 95% confidence interval of 1505 -1724 ppm. This is the preferred LC50 for this study.
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