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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
α,4-dibromotoluene
EC Number:
209-636-5
EC Name:
α,4-dibromotoluene
Cas Number:
589-15-1
Molecular formula:
C7H6Br2
IUPAC Name:
α,4-dibromotoluene

Test animals

Species:
rabbit
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 Hr
Doses:
2000 mg/Kg
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
Signs of dermal irritation noted were very slight erythema and very slight oedema.
Body weight:
Expected bodyweight gains over study period
Gross pathology:
No abnormalities

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 found to be greater than 2000 mg/Kg bw