Registration Dossier
Registration Dossier
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EC number: 209-426-3 | CAS number: 578-58-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Skin sensitization test for human treated with 2-methoxynaphthalene
- Author:
- D.L.J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology. Vol. 13, Pg. 885, 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin sensitization study of 2-methoxynaphthalene was performed by human Maximization test in human
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
- Justification for non-LLNA method:
- No data available
Test material
- Reference substance name:
- Methyl 2-naphthyl ether
- EC Number:
- 202-213-6
- EC Name:
- Methyl 2-naphthyl ether
- Cas Number:
- 93-04-9
- Molecular formula:
- C11H10O
- IUPAC Name:
- 2-methoxynaphthalene
- Details on test material:
- - Name of test material (as cited in study report): Methyl 2-naphthyl ether
- Molecular formula :C11H10O
- Molecular weight :158.19 g/mol
- Substance type: Organic
- Physical state: solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methyl 2-naphthyl ether
- Molecular formula :C11H10O
- Molecular weight :158.19 g/mol
- Substance type: Organic
- Physical state: solid
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% in petrolatum
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- petrolatum
- Concentration / amount:
- 4% in petrolatum
- No. of animals per dose:
- 26 volunteers
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available
Results and discussion
- Positive control results:
- No data available
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 26
- Clinical observations:
- Produced no sensitization reactions.
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
not sensitising to skin
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- The 2-methoxynaphthalene (93-04-9) was considered to be not sensitizing to humans.
- Executive summary:
In skin sensitization study , 26 volunteers were tested by maximization test at a concentration of 4% in petrolatum. No skin sensitization reaction was observed in treated volunteer .therefore, the2-methoxynaphthalene (93-04-9)was considered to be not sensitizing to humans.
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