Registration Dossier
Registration Dossier
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EC number: 204-896-6 | CAS number: 128-58-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- 1981
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- EC Number:
- 204-896-6
- EC Name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- Cas Number:
- 128-58-5
- Molecular formula:
- C36H20O4
- IUPAC Name:
- 16,17-dimethoxyviolanthrene-5,10-dione
- Test material form:
- solid: particulate/powder
- Details on test material:
- C.I. Vat Green 1
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: GAUKLER; OFFENBACH / MAIN, Germany
- Weight at study initiation: 1 male: 2.87 kg; 2 females: 2.85 kg
- Housing: single
- Diet: OVATOR SOLIKANIN 4 MM; MUSKATOR-WERKE DUESSELDORF; Germany; ca 130 g/animal/day
- Water: tap water; ca. 250 mL/animal/day
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 25 June 1984 To: 27. June 1984
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL bulk volume (ca. 65 mg test substance)
- Duration of treatment / exposure:
- 1 hour
- Observation period (in vivo):
- up to 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
- Time after start of exposure: NA
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Vat Green 1 is not irritating to eyes
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