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Diss Factsheets
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EC number: 200-957-6 | CAS number: 76-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methyl-2-nitropropan-1-ol
- EC Number:
- 200-957-6
- EC Name:
- 2-methyl-2-nitropropan-1-ol
- Cas Number:
- 76-39-1
- Molecular formula:
- C4H9NO3
- IUPAC Name:
- 2-methyl-2-nitropropan-1-ol
- Details on test material:
- Purity is above 99%.
Constituent 1
- Specific details on test material used for the study:
- NMP Crystals, 2-nitro-2-methyl-1-propanol, 99.6% purity
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test was conduced using 10 rabbits (5 male; 5 female) weighing 2.9 +/- 0.5 kg. The abdomens of the rabbits were shaved free of hair and the skin in one group of rabbits was further prepared by abrasion.The abrasions were made with a blunt hypodermic needle without obtaining bleeding and were 2-3 cm apart over the area of exposure.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The abdomens of the rabbits were shaved free of hair and the skin in one group of rabbits was further prepared by abrasion.The abrasions were made with a blunt hypodermic needle without obtaining bleeding and were 2-3 cm apart over the area of exposure. Test material was ground to a fine powder. For each rabbit a weight amount of test material to give a dose of 2000 mg/kg was spread over the prepared abdominal are. The skin area was then covered with gauze and a sheet of impervious rubberized cloth to prevent loss of test material. The trunk was further enclosed with a flexible wire screen help in place by tape. Animals were then returned to their cages. After 24 hours the bindings and patches were removed and the exposed skin areas gently cleaned and observed for skin irritancy. The animals wre continued to be oberved for another 14 days.
- Duration of exposure:
- 24 hours
- Doses:
- One dose: 2000 mg/kg
- No. of animals per sex per dose:
- 10 (5 males' 5 females)
- Control animals:
- no
- Details on study design:
- For each rabbit a weight amount of test material to give a dose of 2000 mg/kg was spread over the prepared abdominal are. The skin area was then covered with gauze and a sheet of impervious rubberized cloth to prevent loss of test material. The trunk was further enclosed with a flexible wire screen help in place by tape. Animals were then returned to their cages. After 24 hours the bindings and patches were removed and the exposed skin areas gently cleaned and observed for skin irritancy. The animals wre continued to be oberved for another 14 days for any gross signs of toxicity. At the end of the 14 day observation period the animals were weighed, sacrificed and the organs examined for gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- other: Limit test
- Remarks:
- No signs of toxicity or abnormal behavior. At necropsy organs in all animals were grossly normal
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- None
- Body weight:
- No significant change
- Gross pathology:
- No findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.