Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-112-6 | CAS number: 629-82-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dioctyl ether
- EC Number:
- 211-112-6
- EC Name:
- Dioctyl ether
- Cas Number:
- 629-82-3
- Molecular formula:
- C16H34O
- IUPAC Name:
- 1-(octyloxy)octane
- Test material form:
- liquid
- Details on test material:
- - State of aggregation: Colorless, clear liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): di-n-octylether
- Physical state: colorless liquid
- Purity: >99.9%
- Stability: stable at temperatures up to 40°C
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kleinrussen Chbb:HM
- Details on test animals or tissues and environmental conditions:
- according to guideline
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- application volume: 0.1 mL undiluted
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 72 h after instillation
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- according to guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0.3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 2 - < 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 1 - <= 1.5
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- erythema
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 2.5
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- edema
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- > 2
- Reversibility:
- fully reversible within: 72 h
Any other information on results incl. tables
Table 1: Evaluation of the eye reactions
Animal No. |
Hours after application |
|||||||||||||||||||
1 |
24 |
48 |
72 |
|||||||||||||||||
A |
B |
C |
D |
L |
A |
B |
C |
D |
L |
A |
B |
C |
D |
L |
A |
B |
C |
D |
L |
|
1270 1272 1273 |
0 0 0 |
0 0 0 |
1 2 1 |
1 1 0 |
1 1 0 |
0 0 0 |
0 0 0 |
1 1 0 |
0 1 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 1 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
0 0 0 |
A effects on cornea (turbidity degree)
B effects on iris (intensity)
C erythema (conjunctival reaction)
D edema (conjunctival reaction)
L lacrimation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Only mild effects were observed that were fully reversible within 3 days. Therefore, the substance is considered to be slightly irritating.
- Executive summary:
An aliquot of 0.1 ml aqueous solution of the test article was instilled by a single application for a 24h contact into the eyes of 3 rabbits. The eyes were scored 24, 48 and 72 hours after application. The 24/48/72 hours mean scores were 0 for the cornea, 0 for the iris, 0.33 for the conjunctival erythema and 0.11 for the conjunctival oedema. The conjunctiva reactions abated completely within 72 hours. In summary, only mild effects were observed that were fully reversible. Therefore, the substance is considered to be slightly irritating. GHS criteria for classification and labelling are not fulfilled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
