Registration Dossier
Registration Dossier
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EC number: 203-124-5 | CAS number: 103-56-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Fragrance material review on cinnamyl propionate
- Author:
- S.P. Bhatia a, G.A. Wellington , J. Cocchiara , J. Lalko , C.S. Letizia , A.M. Api
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S1–S23
- Reference Type:
- review article or handbook
- Title:
- A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
- Author:
- The RIFM Expert Panel,D. Belsito , D. Bickers , M. Bruze , P. Calow , H. Greim , J.M. Hanifin , A.E. Rogers , J.H. Saurat , I.G. Sipes , H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology, 45, (2007), S1–S23
- Reference Type:
- secondary source
- Title:
- To study the acute dermal toxicity CINNAMYL PROPIONATE.
- Author:
- D. L. J. OPDYKE
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology. Vol. 12, Pg. 859, 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The acute dermal toxicity of CINNAMYL PROPIONATE was performed on rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Cinnamyl propionate
- EC Number:
- 203-124-5
- EC Name:
- Cinnamyl propionate
- Cas Number:
- 103-56-0
- Molecular formula:
- C12H14O2
- IUPAC Name:
- cinnamyl propionate
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:3-phenylprop-2-en-1-yl propionate, Cinnamyl propionate
Molecular Formula: C12H14O2
Molecular Weight: 190.241 g/mol
InChI: 1S/C12H14O2/c1-2-12(13)14-10-6-9-11-7-4-3-5-8-11/h3-9H,2,10H2,1H3/b9-6+
Substance Type: Organic
Physical State: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- 24hr
- Doses:
- 5000mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:No data available
- Necropsy of survivors performed:/no
- Other examinations performed: clinical signs were observed - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was not observed
- Mortality:
- 1/10(on day 11)
- Clinical signs:
- other: Anorexia and diarrhea were observed in the 1 animal that died
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate (103-56-0)by dermal application
- Executive summary:
Acute dermal toxicity test was performed in 10 rabbits. Test material at dose 5000mg/kg was applied under occlusion for 24hr.Observation made for 14days.1 /10 mortality observed on day 11.Clinical signs like anorexia and diarrhea were observed in the 1 animal that died. No 50% mortality was observed at dose concentration 5000mg/kg bw. Hence theLD50 was considered to be >5000 mg/kg. When rabbits were treated with Cinnamyl propionate(103-56-0)by dermal application
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