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EC number: 204-486-7 | CAS number: 121-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from Danish QSAR database.
- Justification for type of information:
- Data is from Danish QSAR database.
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- Determination of estimated 72 hrs EC50 value of test substance on Pseudokirchneriella subcapitata by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. It is a continuous (Q)SAR model based on structural features and numeric molecular descriptors.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: N-(4-sulfamoylphenyl)acetamide
- Molecular formula: C8H10N2O3S
- Molecular weight: 214.244 g/mol
- Smiles notation: c1(ccc(NC(C)=O)cc1)S(N)(=O)=O
- InChl: 1S/C8H10N2O3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Selenastrum Capricornutum - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 72 h
- Remarks on exposure duration:
- Estimated data
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- No data available
- pH:
- No data available
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Conductivity:
- No data available
- Nominal and measured concentrations:
- No data available
- Details on test conditions:
- No data available
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 161.75 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Domain applicability - Battery : IN
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on inhibition in growth rate of Pseudokirchneriella subcapitata, the estimated 72 hrs EC50 value by three different model i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database was evaluated to be 161.75 mg/l.
- Executive summary:
Based on the prediction done using thethree different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database, the short term toxicity on green algae was predicted for test substance N-(4-sulfamoylphenyl)acetamide(121 -61 -9). The average EC50 value was given by the third model i.e, Battery model. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance N-(4-sulfamoylphenyl)acetamide is estimated to be 161.75mg/l for Pseudokirchneriella subcapitata during 72 hr exposure duration. Thus, on the basis of EC50 value,it can be concluded that the test chemical N-(4-sulfamoylphenyl)acetamide can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered to be not-classified as per the CLP classification criteria.
Reference
Table: Table showing the Pseudokirchneriella subcapitata 72 hr EC50 values estimated by two different models i.e, Leadscope and SciQSAR & the average EC50 value was given by the third model i.e, Battery model.
DK |
Battery |
Leadscope |
SciQSAR |
Pseudokirchneriella subcapitata 72 hr EC50 (mg/l) |
|||
Domain |
IN |
Where,
IN = inside applicability domain
Description of key information
Based on the prediction done using the three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database, the short term toxicity on green algae was predicted for test substance N-(4-sulfamoylphenyl)acetamide(121 -61 -9). The average EC50 value was given by the third model i.e, Battery model. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance N-(4-sulfamoylphenyl)acetamide is estimated to be 161.75mg/l for Pseudokirchneriella subcapitata during 72 hr exposure duration. Thus, on the basis of EC50 value,it can be concluded that the test chemical N-(4-sulfamoylphenyl)acetamide can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered to be not-classified as per the CLP classification criteria.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 161.75 mg/L
Additional information
Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of N-(4-sulfamoylphenyl) acetamide (121-61-9),and RA chemical 4-acetamidobenzenesulfonyl chloride (121-60-8), N-(4-hydroxyphenyl)acetamide (103-90-2) on the growth of green algae. The studies are as mentioned below:
The first weight of evidence study was from Danish QSAR, 2017 for the target chemical, N-(4-sulfamoylphenyl) acetamide. Based on the prediction done using the three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database, the short term toxicity on green algae was predicted for test substance N-(4-sulfamoylphenyl)acetamide(121 -61 -9). The average EC50 value was given by the third model i.e, Battery model. On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance N-(4-sulfamoylphenyl)acetamide is estimated to be 161.75mg/l for Pseudokirchneriella subcapitata during 72 hr exposure duration. Thus, on the basis of EC50 value,it can be concluded that the test chemical N-(4-sulfamoylphenyl)acetamide can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered to be not-classified as per the CLP classification criteria.
In the second weight of evidence study from QSAR, 2017 for the target chemical, N-(4-sulfamoylphenyl) acetamide. Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) was predicted for N-(4-sulfamoylphenyl) acetamide (121-61-9). The EC50 value was estimated to be 156.28 mg/l when N-(4-sulfamoylphenyl) acetamide was exposed toon Desmodesmus subspicatus for 72 hrs.
Similarly another weight of evidence study for N-(4-sulfamoylphenyl) acetamide was taken from ECOSAR, 2017. Based on the prediction done using theEPI Suite ECOSAR version 1.10, the short term toxicity on green algae was predicted for test substance N-(4-sulfamoylphenyl) acetamide (121 -61 -9). On the basis of effects observed in a static freshwater system, the effect concentration EC50 value for the substance is estimated to be 1360mg/l for green algae for 96hrs duration. Based on this value, it can be concluded that the test chemical N-(4-sulfamoylphenyl)acetamide can be considered as non-toxic to green algae at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Similarly the effect of test substance N-acetylsulphanilyl chloride, CAS No. (121-60-8), Lab report Sustainable support service was studied on the growth of fresh water green alga Chlorella vulgaris. The study was conducted following OECD guideline 201- Alga growth inhibition test. The test concentration chosen for the study were 6.25, 12.5, 25, 50, 100 and 200 mg/L were prepared using stock solution of the test substance using de-ionized water. The green alga was exposed to the test concentration for a period of 72 hours to observe average specific growth rate and % growth inhibition under the effect of test substance. EC50 calculated from equation and graphically through probit analysis was observed to be193.43 mg/L and 200 mg/L respectively. Thus chemical was consider as nontoxic to aquatic algae and not classified as per the CLP classification criteria.
The effect of test item paracetamol, CAS No. 103-90-2 which was the RA chemical from UERL lab was studied on the growth of fresh water green alga Chlorella vulgaris. The study was conducted following OECD guideline 201- Alga, growth inhibition test. The test concentration chosen for the study were 6.25mg/l, 12.5mg/l, 25mg/l, 50mg/l, 100mg/l and 200mg/l. The test concentrations were prepared using stock solution of the test item using mineral media. The green alga was exposed to the test concentration for a period of 72 hours to observe average specific growth rate and % growth inhibition under the effect of the test item. EC50 calculated graphically through probit analysis was observed to be 112.666mg/l. Based on this EC50 value and after comparing with CLP criteria for aquatic classification of the substance it is concluded that the substance Paracetamol does not exhibit toxicity to aquatic algae (Chlorella vulgaris).
Similarly in sixth weight of evidence study for N-(4-hydroxyphenyl) acetamide (103-90-2) J-check, 2017, Short term toxicity study of Acetaminophen on the growth of freshwater green algae was carried out for 72 hrs. The effective concentration (EC50) value of N-(4-Hydroxyphenyl) acetamide (Paracetamol) in aquatic green algae in a 72 hr study on the basis of growth rate effect and AUG was > 460 mg/l and 150 mg/l. But the NOEC on the basis of AUG and growth rate was 22 mg/l and 46 mg/l. Based on the growth rate and AUG of green algae by considering EC50 (>460 mg/l), N-(4-Hydroxyphenyl) acetamide was nontoxic and cannot be classified as toxic to aquatic algae as per the CLP classification criteria.
Based on the data obtain from various sources for target and RA chemicals, it can be concluded that the substance N-(4-sulfamoylphenyl) acetamide (121-61-9) is considered to be not toxic to algae and cannot be classified toxic as per the criteria mentioned in CLP regulation.
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