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EC number: 211-105-8 | CAS number: 629-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted in accordance with OECD 402 guideline and was GLP compliant.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted in accordance with OECD 402 guideline and was GLP compliant.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton, Texas
- Weight at study initiation: Weights recorded on day -1
- Fasting period before study: No
- Housing: Individually caged
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 18 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6 to 23.9
- Humidity (%): 36 to 71%
- Photoperiod (hrs dark / hrs light): 12 dark/12 light
IN-LIFE DATES: From: 1981-06-25 To: 1981-07-28 - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Not reported
- % coverage: Not reported
- Type of wrap if used: Surgical gauze secured with tape and covered with aluminium foil and an overwrap of an elastic Ace bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 g/kg
- Constant volume or concentration used: No. Specific amount of test material administered was calculated using fasted body weights on day -1 and specific gravity of 0.673 for Neodene 6.
- Other: Each animal tested had two application sites (1 intact and 1 abraded) - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg Neodene 6, 2 mL/kg deionised water (control)
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations made at 1, 2, 4, and 6 hours following application, at 24 hours and twice daily thereafter until termination of study on day 14.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight - Statistics:
- Statistical analysis for significance of body weight changes included the calculation of the mean and standard error. Determination of the significance of body weight changes on days 7 and 14 compared to controls was made using an independent T-test. A probability level of 0.05 was used as criterion for significance. No information reported on method used to calculate LD50.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths were reported in this study.
- Clinical signs:
- other: No clinical signs of toxicity associated with administration of the test material were reported.
- Gross pathology:
- The only significant findings were related to the exposure sites and included white, crusty material on the skin and fur, alopecia, abrasions, and focal reddened areas.
- Other findings:
- Slight erythema and oedema were observed in all animals treated with Neodene 6 24 hours post-application. The average erythema and oedema scores for abraded skin animals were 0.8 and 1.4, respectively. The average erythema and oedema scores for intact skin animals were 0.5 and 1.2, respectively. All reported Draize scores were 0.0 on day 14 for all animals.
- Interpretation of results:
- other: Not classified
- Remarks:
- Not classified because LD50 is greater than the requirements for a Category 4 toxicant (2000 mg/kg) Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for undiluted Neodene 6 alpha olefin was reported to be >2000 mg/kg in rabbits.
- Executive summary:
In an acute dermal toxicity study, groups of New Zealand White rabbits (4 male, 4 female) were dermally exposed to undiluted Neodene 6 at a dose of 2000 mg/kg bw. Each animal was treated at two application sites; one intact and one abraded. Controls (4 male, 4 female) were treated with deionised water. The treated skin was covered with surgical gauze and held in place with non-irritating adhesive tape, then covered with aluminium foil and an elastic bandage. The exposed area was gently washed after 24 hours of exposure and animals were observed at 1, 2, 4, 6, and 24 hours and twice daily for 14 days. Each exposure site was scored for degree of irritation according to the method of Draize following the removal of the occlusive covering until study termination. Body weights were determined on days -1, 0, 7, and 14. Survivors were necropsied on day 14.
All animals survived until end of study. There were no clinical signs of toxicity or effects on body weight. The skin was the only area affected with minimal irritation noted after the 24 -hour exposure period. By day 14, there was no evidence of irritation; however, at necropsy white crusty material on skin and fur, alopecia, and abrasions and focal reddened areas were noted in treated animals. Abrasions applied prior to treatment did not affect the results. The acute dermal LD50 for undiluted Neodene 6 alpha olefin was reported as >2000 mg/kg in rabbits.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted in accordance with OECD 402 and was GLP compliant.
No tables included based on negative results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Minor deviations were noted in the study, but were determined not to have affected the results.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hex-1-ene
- EC Number:
- 209-753-1
- EC Name:
- Hex-1-ene
- Cas Number:
- 592-41-6
- Molecular formula:
- C6H12
- IUPAC Name:
- hex-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Neodene 6
- Substance type: C6 alpha olefin
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ray Nichols Rabbitry, Lumberton, Texas
- Weight at study initiation: Weights recorded on day -1
- Fasting period before study: No
- Housing: Individually caged
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 18 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.6 to 23.9
- Humidity (%): 36 to 71%
- Photoperiod (hrs dark / hrs light): 12 dark/12 light
IN-LIFE DATES: From: 1981-06-25 To: 1981-07-28
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Not reported
- % coverage: Not reported
- Type of wrap if used: Surgical gauze secured with tape and covered with aluminium foil and an overwrap of an elastic Ace bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 g/kg
- Constant volume or concentration used: No. Specific amount of test material administered was calculated using fasted body weights on day -1 and specific gravity of 0.673 for Neodene 6.
- Other: Each animal tested had two application sites (1 intact and 1 abraded) - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg Neodene 6, 2 mL/kg deionised water (control)
- No. of animals per sex per dose:
- 4
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations made at 1, 2, 4, and 6 hours following application, at 24 hours and twice daily thereafter until termination of study on day 14.
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight - Statistics:
- Statistical analysis for significance of body weight changes included the calculation of the mean and standard error. Determination of the significance of body weight changes on days 7 and 14 compared to controls was made using an independent T-test. A probability level of 0.05 was used as criterion for significance. No information reported on method used to calculate LD50.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths were reported in this study.
- Clinical signs:
- other: No clinical signs of toxicity associated with administration of the test material were reported.
- Gross pathology:
- The only significant findings were related to the exposure sites and included white, crusty material on the skin and fur, alopecia, abrasions, and focal reddened areas.
- Other findings:
- Slight erythema and oedema were observed in all animals treated with Neodene 6 24 hours post-application. The average erythema and oedema scores for abraded skin animals were 0.8 and 1.4, respectively. The average erythema and oedema scores for intact skin animals were 0.5 and 1.2, respectively. All reported Draize scores were 0.0 on day 14 for all animals.
Any other information on results incl. tables
No tables included based on negative results.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Not classified because LD50 is greater than the requirements for a Category 4 toxicant (2000 mg/kg) Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for undiluted Neodene 6 alpha olefin was reported to be >2000 mg/kg in rabbits.
- Executive summary:
In an acute dermal toxicity study, groups of New Zealand White rabbits (4 male, 4 female) were dermally exposed to undiluted Neodene 6 at a dose of 2000 mg/kg bw. Each animal was treated at two application sites; one intact and one abraded. Controls (4 male, 4 female) were treated with deionised water. The treated skin was covered with surgical gauze and held in place with non-irritating adhesive tape, then covered with aluminium foil and an elastic bandage. The exposed area was gently washed after 24 hours of exposure and animals were observed at 1, 2, 4, 6, and 24 hours and twice daily for 14 days. Each exposure site was scored for degree of irritation according to the method of Draize following the removal of the occlusive covering until study termination. Body weights were determined on days -1, 0, 7, and 14. Survivors were necropsied on day 14.
All animals survived until end of study. There were no clinical signs of toxicity or effects on body weight. The skin was the only area affected with minimal irritation noted after the 24 -hour exposure period. By day 14, there was no evidence of irritation; however, at necropsy white crusty material on skin and fur, alopecia, and abrasions and focal reddened areas were noted in treated animals. Abrasions applied prior to treatment did not affect the results. The acute dermal LD50 for undiluted Neodene 6 alpha olefin was reported as >2000 mg/kg in rabbits.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was conducted in accordance with OECD 402 and was GLP compliant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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