Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-909-2 | CAS number: 6831-82-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06.02.2017 to 13.03.2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Potassium propan-2-olate
- EC Number:
- 229-909-2
- EC Name:
- Potassium propan-2-olate
- Cas Number:
- 6831-82-9
- Molecular formula:
- C3H8O.K
- IUPAC Name:
- potassium propan-2-olate
- Test material form:
- liquid
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 500 μL
- Duration of treatment / exposure:
- max. 4 h
- Number of replicates:
- 4
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- mean breakthrough time (min)
- Value:
- ca. 16.5
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other:
- Remarks:
- exact mean breakthrough time (min:s): 16:31
- Other effects / acceptance of results:
- Break throughtime range of all vials: 15:44 - 17:24 min
Applicant's summary and conclusion
- Conclusions:
- Based on the observed results and applying the evaluation criteria cited in chapter 3.8 it was concluded, that Potassium Isopropylate shows a corrosive potential
in the Corrositex® - Skin Corrosion Test under the test conditions chosen. The mean breakthrough time determined in the in vitro membrane barrier test
was 16 minutes and 31 seconds2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
