Registration Dossier
Registration Dossier
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EC number: 225-184-1 | CAS number: 4702-90-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Body weights were not determined at the end of the study.
- Principles of method if other than guideline:
- Noakes and Sanderson, A method for determining the dermal toxicity of pesticides, Brit. Journ. Ind. Med. 26, 59 (1969)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- EC Number:
- 225-184-1
- EC Name:
- 4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one
- Cas Number:
- 4702-90-3
- Molecular formula:
- C21H18N4O2
- IUPAC Name:
- 4,4'-methylylidenebis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)
- Details on test material:
- - Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight at study initiation: mean 138 g (male), 137 g (female)
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back of animals, 50cm2
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.6 - 0.8 g
- Concentration: 50%
- Constant volume or concentration used: yes - Duration of exposure:
- one application
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross necropsy
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No adverse effects were observed.
- Mortality:
- no mortalities
- Clinical signs:
- other: no abnormalities found
- Gross pathology:
- no abnormalities found
- Other findings:
- yellow substance residues on the skin, observed until day 5 post application.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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