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EC number: 203-142-3 | CAS number: 103-76-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Exposure based adaptation of information requirements:
According to REGULATION (EC) No 1907/2006, Annex IX and Annex X, repeated dose/reproduction toxicity testing (section 8.6/section 8.7) may be omitted, if relevant human exposure can be excluded in accordance with Annex XI section 3. Furthermore and in accordance with section 3.2 (b) of Annex XI (as amended by Regulation 134/2009), testing for repeated dose toxicity/reproduction toxicity can be omitted when the substance is not incorporated in an article and the manufacturer can demonstrate and document for all relevant scenarios that throughout the life cycle strictly controlled as well as rigorously contained conditions as set out in Article 18(4)(a) to (f) (Regulation 1907/2006) apply.
Life-cycle stage(s) covered:
1. Production of Hydroxyethylpiperazine (PROCs 1, 2, 3, 8b, 15)
2. Formulation of Hydroxyethylpiperazine into a mixture (PROCs 1, 2, 3)
3. Use of Hydroxyethylpiperazine in gas treatment (PROCs 1, 2, 3)
4. Intermediate use (PROCs 1, 2, 3, 15)
Classification:
H315: Causes skin irritation.
H318: Causes serious eye damage.
The substance is considered as corrosive to the eyes and capable of causing skin irritating effects. Based on the bacterial reverse mutation assay, the HPRT assay, and the CA test the test substance is not considered to induce gene mutations neither in the absence nor in the presence of a metabolic activation system.
1. Process description: PRODUCTION
Piperazine solution and ethylenoxide are transferred via closed pipelines to thereactor. After the flow and temperature controlled reaction is completed, the produced crude hydroxyethylpiperazine (HEP) is transferred via a closed pipeline to the distillation column. Sampling is done with a closed system.
The whole process is operated discontinuously at elevated temperature. The reactor is located indoors. Due to the closed system, exposure to workers will not take place under normal operation conditions.
In the distillation process the crude HEPis separated in 3 fractions: light boiler, intermediate fraction and the pure fraction. The residue remains in the distillation vessel. The pure product is pumped from the vessel via a closed pipeline to the drum filling station.
Transfers, storage tank, reactor, processing equipment and feeds are operated in fully closed systems. Exposure is limited to occasional sampling tasks for quality control under strictly control conditions.Only a small, well-defined and trained group of workers is exposed occasionally to low levels using appropriate risk management measures to minimize exposure.
2. Process description GAS TREATMENT:
The Feed Gas enters the Absorber at the bottom. The lean solution is fed at the top of the absorber and hence the liquid and the gas are getting in contact in a counter-current flow. The mass and heat exchange is performed in the packing sections installed in the absorber. The Treated Gas leaves the Absorber with a CO2 concentration < 2% as desired, to the pipeline or for further processing. The rich solution from the bottom of the absorber is fed to the HP flash vessel, operated at a pressure level between absorber pressure and Stripper pressure. A level control valve is used to reduce the pressure of the rich solution from the level of the absorber to the level of the HP flash. The Flash Gas from the HP flash vessel contains the major part of the dissolved inert gases, i.e. non-acid gases like methane, and a minor part of the acid gas. The solution is heated up in the heat exchanger whereby a smaller amount of gas might be released from the solution. A larger amount of gas is released after the solution has passed the let-down valve, which controls the level in the HP flash vessel. The solution is then flashed at the top of the Stripper where vapor and liquid separate. Most of the absorbed CO2 and H2S is stripped off by steam generated in the reboiler. The regenerated solution leaves the stripper bottom with only a very low residual acid gas loading. The heat from this stream is partly recovered in the heat exchanger. The Stripper vessel is furnished with a packed bed in order to provide a large surface area required to release the CO2. The lean solution is then cooled down further in the lean solution cooler and fed to the top of the lean absorber. A reflux condenser is installed on top of the Stripper vessel for cooling down the released acid gas and condensing a part of the steam. The remaining gas stream with the major part of the acid gas (Acid Off-Gas) leaves the condenser for downstream processing. The condensate is pumped back to the top of the Stripper vessel. An appropriate amount of water is fed to the unit for balancing the amount of vapor leaving the unit with the gas streams.
All vessels, pumps, heat exchangers, processing equipment and feeds are operated in fully closed systems. Exposure is limited to occasional sampling and shutdown tasks for quality control under strictly control conditions. Only a small, well-defined and trained group of workers is exposed occasionally to low levels using appropriate risk management measures to minimize exposure.
The whole process is operated continuously at elevated temperature and pressure. All vessels are located outdoors. Due to the closed system, exposure to workers will not take place under normal operation conditions.
Rigorous containment measures:
The substance is manufactured and used under strictly controlled conditions over the entire life cycle. Exposure is limited to occasional sampling tasks for quality control, as well as to charging and discharging processes. Transport, storage tanks, reactors, processing equipment, and feeds operate in fully closed systems.
Procedural and control technologies are used to minimize residual emissions/exposure as well as qualitative risk considerations:
Operational and technical conditions and measures affecting and controlling workers exposure, such as local exhaust ventilation as well as personal protective equipment, such as goggles, chemically resistant gloves, and respiratory protection where potential exposure may occur as reported in the CSR are followed (see chapters 9 &10).
On the basis of the described process conditions, testing of Repeated Dose Toxicity (OECD TG 407) as well as Reproductive Toxicity (OECD TG 421 or 422) was not performed since the criteria of exposure based adaptation of information requirements are met.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Mode of Action Analysis / Human Relevance Framework
No further information available.
Additional information
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Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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