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EC number: 216-938-0 | CAS number: 1703-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from NTP and NTRL report.
- Justification for type of information:
- Data is from NTP and NTRL report.
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database.
- Title:
- Acute oral toxicity test in rats.
- Author:
- Arthur D. Little, Inc.
- Year:
- 1 991
- Bibliographic source:
- EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION,NATIONAL TOXICOLOGY PROGRAM
- Reference Type:
- secondary source
- Title:
- Acute Oral Toxicity (LD50) test in rats
- Author:
- Mallinckrodt INC
- Year:
- 1 980
- Bibliographic source:
- NTIS Report, OTS – 02800059 - IN
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity was access in rats using Butane-1,2,3,4-tetracarboxylic acid.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Butane-1,2,3,4-tetracarboxylic acid
- EC Number:
- 216-938-0
- EC Name:
- Butane-1,2,3,4-tetracarboxylic acid
- Cas Number:
- 1703-58-8
- Molecular formula:
- C8H10O8
- IUPAC Name:
- butane-1,2,3,4-tetracarboxylic acid
- Test material form:
- solid
- Details on test material:
- - Name of the test chemical: Butane-1,2,3,4-tetracarboxylic acid- IUPAC name: Butane-1,2,3,4-tetracarboxylic acid - Molecular Formula: C8H10O8- Molecular Weight: 234.159 g/mol- Smile Notation: OC(=O)C[C@H]([C@H](CC(=O)O)C(=O)O)C(=O)O- InChI : 1S/C8H10O8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4H,1-2H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)/t3-,4+- Substance type: organic
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Butane-1,2,3,4-tetracarboxylic acidMolecular Formula: C8H10O8Molecular Weight: 234.159 g/molSmile Notation: OC(=O)C[C@H]([C@H](CC(=O)O)C(=O)O)C(=O)OInChI : 1S/C8H10O8/c9-5(10)1-3(7(13)14)4(8(15)16)2-6(11)12/h3-4H,1-2H2,(H,9,10)(H,11,12)(H,13,14)(H,15,16)/t3-,4+Substance type: organic Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- other: COX-SD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALSWeight at study initiation:198-293gmFasting period before study: yes, overnight fasting Housing: Metal wire bottomed cagesDiet (e.g. ad libitum): Purina Rodent Laboratory Chow, ad libitiumWater (e.g. ad libitum):Tap water, ad libitium IN-LIFE DATES: From: To: one group was dosed at 21/8/79 and second group 17/10/79 and sacrificed on 31/10/79
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Distilled water
- Details on oral exposure:
- VEHICLEConcentration in vehicle: 10%(w/w)MAXIMUM DOSE VOLUME APPLIED: 3170g/kgbw Rationale for the selection of the starting dose: Prior to the actual LD50 determination, exploratory doses were administered to eight rats to estimate the order of toxicity of the test material. Based on the results of the preliminary assay, groups of ten rats (five males and five females) were dosed at intervals spaced so as to provide a suitable dosage mortality curve for quantitative assessment of oral LD50
- Doses:
- 800, 1260, 1590, 2000 and 3170mg/kgbw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?): 14 days- Frequency of observations and weighing: Observations for gross signs were performed at regular intervals on the day of dosage and 5 days per week and thereafter for fourteen days, Surviving animals were weighed seven days post-treatment.- Necropsy of survivors performed: Yes
- Statistics:
- LD50 with confidence limits and slope function with confidence limits (method of Litchfield and Wilcoxon)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 720 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 420 - < 2 080
- Mortality:
- Cumulative Mortality dataDosage Level mg/kgbw% Mortality80001260101590202000803170100
- Clinical signs:
- other: Slight to severe hypoactivity,hypersalivation, diarrhea. unkempt pelage, piloerection, malaise and proneness were seen.
- Gross pathology:
- Moderate to severe congestion of the kidneys, adrenaIs , lungs, liver and intestines, scattered brownish lesions and/or erosion of the mucosa of the stomach (opaque portion), blanching of the mucosa of the stomach (opaque and translucent portions) and small intestine, paleness of the liver (underside of lobes) and brownish-gray coloration throughout the lungs.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 of BTCA , when administered to 5 male COX-SD rats was considered to be 1740mg/kgbw, with a confidence interval of 1330 to 2280mg/kgbwThe acute oral LD50 of BTCA , when administered to 5 female COX-SD rats was considered to be 1620mg/kgbw.
- Executive summary:
Acute oral toxicity test was performed in rats COX-SD strain for a period of 14 days. The rats have 198-293gm and metal wire bottomed cages were used for the housing of rats. The chemical was given orally in the form of gavage in distilled water. 5 animals per sex per dose were used in 800, 1260, 1590, 2000 and 3170 mg/kg bw concentrations. Observations for gross signs were performed at regular intervals on the day of dosage and 5 days per week and thereafter for fourteen days. Necropsy of survivors was also done at termination of the study.
Body weight were observed in animals some has constant weight and some has slight decrease in weight was observed.
Moderate to severe congestion of the kidneys, adrenaIs , lungs, liver and intestines, scattered brownish lesions and/or erosion of the mucosa of the stomach (opaque portion), blanching of the mucosa of the stomach (opaque and translucent portions) and small intestine, paleness of the liver (underside of lobes) and brownish-gray coloration throughout the lungs.
The acute oral LD50 of BTCA , when administered to 5 male COX-SD rats was considered to be 1740 mg/kgbw, with a confidence interval of 1330 to 2280 mg/kg bw.The acute oral LD50 of BTCA , when administered to 5 female COX-SD rats was considered to be 1620 mg/kgbw.
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