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EC number: 225-234-2 | CAS number: 4731-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-03-11 to 1985-05-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trioctylphosphine
- EC Number:
- 225-234-2
- EC Name:
- Trioctylphosphine
- Cas Number:
- 4731-53-7
- Molecular formula:
- C24H51P
- IUPAC Name:
- trioctylphosphane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Hazleton-Dutchland, Inc. Denver, Pennsyvania
- Age at study initiation: Young adults
- Housing: Individually housed
- Cages: Suspended, stainless steel
- Diet (e.g. ad libitum): Lab Rabbit Chow HF (Purina #5326)
- Water (e.g. ad libitum): Automatic watering system Municipal water supply (Elyzabethtown water Co.)
- Acclimation period: 15 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 15.6 to 21.1 °C (60 - 70 °F)
- Humidity (%):30 - 70 %
- Photoperiod (hrs dark / hrs light): 12h / 12h
IN-LIFE DATES: From: To:1985-05-26 to 1985-05-29
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent negative control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.1 mL - Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 6 (2 males and 4 females)
- Details on study design:
- SCORING SYSTEM: Draize Scale
TOOL USED TO ASSESS SCORE: fluorescein dye was used to confirm presence of absence of corneal ulceration.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 10
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 10
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 8
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 10
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 12
- Max. score:
- 110
- Reversibility:
- not specified
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- animal #6
- Time point:
- 24 h
- Score:
- 12
- Max. score:
- 110
- Reversibility:
- not specified
Any other information on results incl. tables
Summary of responses and maximum Draize Scores
Animal number |
Cornea |
Iris |
Conjunctivae |
Score |
First time obtained |
Time clearb |
|||
|
Opacity |
Ulceration |
|
Redness |
Chemosis |
Necrosis or Ulceration |
|
|
|
6422 F |
- |
- |
- |
- |
+ |
- |
10 |
24h |
C |
6423 M |
- |
- |
- |
- |
+ |
- |
10 |
24h |
C |
6424 F |
- |
- |
- |
- |
- |
- |
8 |
24h |
C |
6426 F |
- |
- |
- |
- |
+ |
- |
10 |
24h |
C |
6427 M |
- |
- |
- |
+ |
+ |
- |
12 |
24h |
C |
6406 F |
- |
- |
- |
+ |
+ |
- |
12 |
24h |
C |
b : time clear is time that eye was free of all irritation
C: Not clear at termination of study (Day 3)
M: male
F: female
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The substance produced generally mild irritation which consisted primarilly of conjunctival redness, chemosis and discharge, with the most severe effects occuring at 24h. In five o the six animals, scores fo conjunctival chemosis and/or redness were considered positive irritant response. No corneal ulceration or opacity or iridial damage were seen. Periorbital irritaion (erythema, chemosis, alopecia, necrosis and:or desquamation) was evident in all six animals. Irritation persisted through study termination (72h), although some recovery from the 24-hour observations was apparent.
- Executive summary:
In an in vivo eye irritation study, 0.1 mL of trioctylphosphine was applied into eye of rabbit.
Observations at 24h, 48h and 72h after application showed effects on Conjuntivae and Cornea.
Taking into accoun t thereulsts, the substance was considered to be irritating to the eye.
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