Registration Dossier
Registration Dossier
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EC number: 230-660-7 | CAS number: 7250-67-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Henry F. Smyth Jr. Ph.D. , Charles P. Carpenter Ph.D. , Carrol S. Weil , Urbano C. Pozzani , Jean A. Striegel & Judith S. Nycum
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, 30:5, 470-476, 1969
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of aluminium triisopropanolate in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Aluminium triisopropanolate
- Cas Number:
- 555-67-1
- Molecular formula:
- C3H8O.1/3Al C9H21AlO3 C9H21O3.Al
- IUPAC Name:
- Aluminium triisopropanolate
- Details on test material:
- - Name of test material (as cited in study report): aluminium triisopropanolate
- Molecular formula (if other than submission substance): C3H8O.1/3Al
C9H21AlO3
C9H21O3.Al
- Molecular weight (if other than submission substance): 204.2439 g/mole
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): aluminium triisopropanolate
- Molecular formula (if other than submission substance): C3H8O.1/3Al
C9H21AlO3
C9H21O3.Al
- Molecular weight (if other than submission substance): 204.2439 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 11300 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 11 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 7 000 - 18 300
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed at 11300 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 11300 mg/kg/bw (7000- 18300) when rats were treated with aluminium triisopropanolate orally.
- Executive summary:
In aacute oral toxicity study,rats were treated with aluminium triisopropanolate orally. 50 % mortality was observed at11300mg/kg bw. Therefore,LD 50 was considered to be 11300 mg/kg/bw (7000- 18300) when rats were treated with aluminium triisopropanolate orally
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