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EC number: 944-003-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
There are no reliable data available on the aquatic toxicity of EC# 944-003-3 and reliable data cannot be obtained because the substance degrades rapidly at pH <11 to form highly volatile carbon disulphide (CS2). In a well documented study conducted according to DIN 38 412, DEV L15 and OECD principles for GLP, the acute toxicity (48-hr LC50) of EC# 944-003-3 to freshwater fish species Leuciscus idus (L.) was determined to be 55 mg/l. However, significant deficiencies in the study design exist. Specifically, there was no analytical monitoring and there was no consideration given to the degradation of the substance to carbon disulphide and losses of carbon disluphide due to volatilization. Sufficient data on CS2 do exist, however, and these data can be used to estimate the aquatic toxicity of EC# 944 -0033. In a static test with CS2 in a sealed system to determine the toxicity of CS2 to Daphnia magna, the 48-h EC50 for CS2 was 2.1 mg/l. The test fulfilled the requirements of OECD Guideline 202 but was not carried out in compliance with GLP. From these data, the toxicity of the substance being registered (EC# 944-003-3) is estimated to be 55 mg/l. The basis for this estimate is attached as background information in the supporting study for aquatic invertebrates (read-across to CS2). In addition, a test in sealed infusion bottles was carried out to determine the toxicity of CS2 to the alga Chlorella pyrenoidosa. The test was similar to the OECD Guideline 201, but was not carried out in compliance with GLP. The 96-h ErC50 for Chlorella pyrenoidosa was 21 mg/L. From these data, the toxicity of the substance being registered (EC# 944-003-3) is estimated to be 554 mg/l. The basis for this estimate is attached as background material in the supporting study for aquatic algae (read-across to CS2). From these data, coupled with the knowledge that CS2 is expected to be the only degradant produced at concentrations disproportionate to substances naturally present in the environment, and given that CS2 does not persist in the environment, it is reasonable to conclude that the substance being registered (EC# 944-003-3) does not meet current CLP criteria for classification as dangerous for the environment.
Additional information
There are no reliable data available on the aquatic toxicity of EC# 944-003-3 and relaible data cannot be obtained because the substance degrades rapidly at pH <11 to form highly volatile carbon disulphide (CS2). In a well documented study conducted according to DIN 38 412, DEV L15 and OECD principles for GLP, the acute toxicity (48-hr LC50) of EC# 944-003-3 to freshwater fish species Leuciscus idus (L.) was determined to be 55 mg/l. However, significant deficiencies in the study design exist. Specifically, there was no analytical monitoring and there was no consideration given to the degradation of the substance to carbon disulphide and losses of carbon disluphide due to volatilization. Sufficient data on CS2 do exist, however, and these data can be used to estimate the aquatic toxicity of EC# 944 -0033. In a static test with CS2 in a sealed system to determine the toxicity of CS2 to Daphnia magna, the 48-h EC50 for CS2 was 2.1 mg/l. The test fulfilled the requirements of OECD Guideline 202 but was not carried out in compliance with GLP. From these data, the toxicity of the substance being registered (EC# 944-003-3) is estimated to be 55 mg/l. The basis for this estimate is attached as background information in the supporting study for aquatic invertebrates (read-across to CS2). In addition, a test in sealed infusion bottles was carried out to determine the toxicity of CS2 to the alga Chlorella pyrenoidosa. The test was similar to the OECD Guideline 201, but was not carried out in compliance with GLP. The 96-h ErC50 for Chlorella pyrenoidosa was 21 mg/L. From these data, the toxicity of the substance being registered (EC# 944-003-3) is estimated to be 554 mg/l. The basis for this estimate is attached as background material in the supporting study for aquatic algae (read-across to CS2).From these data, coupled with the knowledge that CS2 is expected to be the only degradant produced at concentrations disproportionate to substances naturally present in the environment, and given that CS2 does not persist in the environment, it is reasonable to conclude that the substance being registered (EC# 944-003-3) does not meet current CLP criteria for classification as dangerous for the environment.
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