2,2,4,4,6,6-hexamethylcyclotrisilazane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The key study was conducted according to a protocol similar to OECD test guideline, with acceptable restrictions. The study was not compliant with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

groups of only three male and three female animals per dose; observation period was less than 14 days.

GLP compliance:

no

Remarks:

The study pre-dates GLP

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

2,2,4,4,6,6-hexamethylcyclotisilazane

IUPAC Name:

2,2,4,4,6,6-hexamethylcyclotisilazane

Constituent 2

Reference substance name:

2,2,4,4,6,6-hexamethylcyclotrisilazane

EC Number:

213-773-6

EC Name:

2,2,4,4,6,6-hexamethylcyclotrisilazane

Cas Number:

1009-93-4

Molecular formula:

C6H21N3Si3

IUPAC Name:

2,2,4,4,6,6-hexamethyl-1,3,5,2,4,6-triazatrisilinane

Test material form:

not specified

Test animals

Species:

mouse

Strain:

CD-1

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River France

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

peanut oil

Details on oral exposure:

No details provided in report.

Doses:

670, 1000, 1500, 2250 and 3370 mg/kg bw

No. of animals per sex per dose:

3 males and 3 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 10 days

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 700 mg/kg bw

Based on:

not specified

Mortality:

No mortalities occurred in the 670 and 1000 mg/kg bw groups. After ten days, the mortalities in the other groups were as follows: 1500 mg/kg bw three out of six; 2250 mg/kg bw four out of six; 3370 mg/kg bw six out of six .

Clinical signs:

other: At all doses tested the animals showed slight sedation, stiffness and increased sensitivity to sound and touch. At toxic doses death followed tonic convulsions, appearing during the first 24 hours. Animals which survived were symptom-free after two days.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

In an acute toxicity study, 2,2,4,4,6,6-hexamethylcyclotrisilazane was administered orally to groups of three male and three female mice at doses of 670, 1000, 1500, 2250 and 3370 mg/kg bw. The reporting of the study was limited. It was concluded that the LD50 was 1700 mg/kg bw.