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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Contribution to the Pharmacology of the Benzothiazoles
Author:
MARSTON TAYLOR BOGERT and HELEN G. HUSTED
Year:
1932
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics, June 1932, 45 (2) 189-207

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical:1,3-benzothiazol-2-amine
Common Name: 2-aminobenzothiazole
Molecular Formula:C7H6N2S
Molecular Weigth: 150.2044 g/mol
Substance Type: Organic
InChI: 1S/C7H6N2S/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H2,8,9)
Physical State: Solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
undiluted test chemical
Duration of treatment / exposure:
Single exposure
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
TEST SITE
- Area of exposure: conjunctival sac

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
There was neither local nor central action when the test chemical was applied to the conjunctival sac of rabbits.
Hence, the test chemical can be considered not irritating to rabbit eyes.
Executive summary:

The ocular irritation potential of the test chemical was assessed in rabbits.

The test chemical was applied to the conjunctival sac of rabbits and observed for signs of irritation (dose and duration not mentioned).

There was neither local nor central action when the test chemical was applied to the conjunctival sac of rabbits.

Hence, the test chemical can be considered not irritating to rabbit eyes.