Registration Dossier
Registration Dossier
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EC number: 221-602-1 | CAS number: 3158-91-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Read Across from CDD (CAS. 50892-62-1)
Data source
Materials and methods
- Principles of method if other than guideline:
- The Leadscope® Model Applier software, which includes two (Q)SAR prediction methodologies that complement each other (expert rule-based alerts and statistical-based QSAR model), has been used for the assessment. Negative results for bacterial mutagenicity have been obtained with both statistical (Salmonella Mut v3) and expert alerts (Bacterial Mut v2).
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other:
- Metabolic activation:
- with and without
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- No genotoxic potential based on QSAR
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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