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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Drugs in Japan Vol. -, Pg. 740, 1995.
Year:
1995
Bibliographic source:
ChemId plus Lite data base; RTECS Number: AB6680000

Materials and methods

Principles of method if other than guideline:
Method not available
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiamphenicol
EC Number:
239-355-3
EC Name:
Thiamphenicol
Cas Number:
15318-45-3
Molecular formula:
C12H15Cl2NO5S
IUPAC Name:
2,2-dichloro-N-{2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met