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EC number: 254-751-6 | CAS number: 40018-26-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-07-02 to 2004-11-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- The determination was carried out using the flask method, Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1,4-dithiane-2,5-diol
- EC Number:
- 254-751-6
- EC Name:
- 1,4-dithiane-2,5-diol
- Cas Number:
- 40018-26-6
- Molecular formula:
- C4H8O2S2
- IUPAC Name:
- 1,4-dithiane-2,5-diol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: approximately 4°C, in the dark
Results and discussion
Water solubility
- Key result
- Water solubility:
- 5.17 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 10 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- >= 5.4 - <= 5.6
Any other information on results incl. tables
Preliminary test
The preliminary estimate of water solubility was 4.67 g/L.
Definitive test
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
24 |
5.19 |
5.6 |
2 |
48 |
24 |
5.07 |
5.4 |
3 |
72 |
24 |
5.26 |
5.5 |
Mean concentration: 5.17 g/L at 20.0 ± 0.5ºC
Range: 5.07 to 5.26 g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 2.5 g/L. This was satisfactory with a correlation coefficient of 0.999 being obtained.
Recovery of analysis of the sample procedure was assessed and proved adequate for the test.
At a nominal concentration of 4.5 g/L, a mean percentage recovery of 90.3% was obtained (range 89.3 to 91.5%).
Concentrations have been corrected for recovery of analysis.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the test material has been determined to be 5.17 g/L of solution at 20.0 ± 0.5°C.
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