1-(chloromethyl)naphthalene

Endpoint summary

Description of key information

Acute toxicity oral in rat was reported as LD50 890 mg/kg.

Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1967

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: collection of data, but record lacks methodological details

Principles of method if other than guideline:

no data on guideline, Study period lies before the acceptance of guidelines

GLP compliance:

not specified

Remarks:

Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.

Test type:

other: no data, but probable standard acute method

Specific details on test material used for the study:

no specific details given

Species:

rat

Route of administration:

oral: unspecified

Key result

Dose descriptor:

LD50

Effect level:

ca. 890 mg/kg bw

Based on:

not specified

Interpretation of results:

Category 4 based on GHS criteria

Executive summary:

Acute toxicity oral in rat was reported in RTECS as LD50 890 mg/kg,

Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947 -69

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

890 mg/kg bw

Quality of whole database:

Study period lay before the acceptance of guidelines, but reliable authors

Acute toxicity: via dermal route

Link to relevant study records

Reference

Reference 1

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1967

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: collection of data, but record lacks methodological details

Principles of method if other than guideline:

Probably standard dermal toxicity study

GLP compliance:

not specified

Remarks:

Data retrieval was performed in 2016 by using RTECS. Toxicity values without further details are given. The cited reference lacks information on GLP compliance and year of study.

Test type:

standard acute method

Specific details on test material used for the study:

no data given

Species:

rabbit

Key result

Dose descriptor:

LD50

Effect level:

ca. 2 000 mg/kg bw

Interpretation of results:

Category 4 based on GHS criteria

Executive summary:

Acute toxicity dermal in rabbit was reported as LD50 2000 mg/kg.

Toxicity data reference: Industrial Hygiene Foundation of America, Chemical and Toxicilogical Series, Bulletin (Pittburgh, Pa) 1947

Reference 2

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1990

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: collection of data, but record lacks methodological details

Specific details on test material used for the study:

98,9 - 100,2 %

Species:

rat

Strain:

Wistar

Sex:

male/female

Type of coverage:

not specified

Doses:

0, 200, 1000, 5000 mg/kg bw.

No. of animals per sex per dose:

5

Control animals:

yes

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

no

Interpretation of results:

Category 5 based on GHS criteria

Executive summary:

Acute toxicity dermal in rat was reported in RTECS as LD50 >5000 mg/kg.

Data from Kiso to Rinsho Clinical Report (Yubunsha Co., Ltd., 1 -5. Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

2 000 mg/kg bw