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EC number: 258-751-7 | CAS number: 53767-93-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Test conducted prior to the GLP guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: FDA of the United States
- Version / remarks:
- FDA of the United States (Fed. Reg .28 (119), 5582 1963)
- Qualifier:
- according to guideline
- Guideline:
- other: Draize and Kelley
- Version / remarks:
- Draize and Kelley (Drug Cosmet. Industr. 71 (1952) 36)
- GLP compliance:
- no
- Remarks:
- Test conducted priro to the GLP guidelines
Test material
- Reference substance name:
- 2,6-dimethyloct-7-en-2-yl acetate
- EC Number:
- 258-751-7
- EC Name:
- 2,6-dimethyloct-7-en-2-yl acetate
- Cas Number:
- 53767-93-4
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2,6-dimethyloct-7-en-2-yl acetate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Clear colorless liquid designed Dihydromyrcenylacetate (Institute's code: DHMA) was received on 19th Januray, 1979.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Twelve healthy adult albino rabbits are used
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of undiluted the test substance is brought on the skin
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- Six rabbits are treated on the intact skin and Six others on the abraded skin
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin, also animal 8959 and 8960
- Remarks:
- 24 and 72 hours were scored
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin, also animal 8961
- Remarks:
- 24 and 72 hours were scored
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin, 1 animal
- Remarks:
- 24 and 72 hours were scored
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin, 5 animals; 5857, 8959, 8960, and 8961
- Remarks:
- 24 and 72 hours were scored
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: intact skin, 1 animal
- Remarks:
- 24 and 72 hours were scored
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: 1 animal
- Remarks:
- 24 and 72 hours were scored
Any other information on results incl. tables
After 24 hours the skin reactions observed generally consisted of very slight or well-defined erythema and very slight or slight oedema.
After 72 hours the skin reactions generally consisted of well defined erythema, very slight oedema and distinct scaliness.
There were no disctinct differences between reactions of the intact and those of the abraded skin. From these results it appear that DHMA is a moderate primary skin irritant.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not a skin irritant.
- Remarks:
- According to EU CLP (EC No. 1272/2008 and its amendments).
- Conclusions:
- The substance is not a skin irritant in the OECD TG 404 using EU CLP criteria, but it is classified Category 3 (mild irritant) based on GHS criteria.
- Executive summary:
The substance was examined for primary skin irritation according to the Draize and Kelley (Drug Cosmet. Industr. 71 (1952) 36) and FDA of the United States (Fed. Reg .28 (119), 5582 1963) methods somewhat similar to OECD TG 404. Six rabbits, previously clipped on the backs, are treated on the intact skin and Six others on the abraded skin with 0.5 ml of the undiluted test material. After an exposure of 24 hours the patches and the material applied are removed and the resulting skin reactions are evaluated by the method of Draize. A second reading is made 48 hours later (72 hours application). After 24 hours the skin reactions observed generally consisted of very slight or well-defined erythema and very slight or slight oedema. After 72 hours the skin reactions generally consisted of well defined erythema, very slight oedema and distinct scaliness. There were no disctinct differences between reactions of the intact and those of the abraded skin.
From the results of the present study it can be concluded that the substance irritation seen is insufficient for being a skin irritant.
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