Registration Dossier
Registration Dossier
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EC number: 944-260-1 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation of the target2-Benzyl-4-(dimethylamino)butanoic acidwas estimated by using the following predictors: Derek Nexus, Sarah Nexus, Vega (four models).
The predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction. In the weight of evidence assessment only reliable predictions are to be taken into account.
Vega models predicted the target compound as non-mutagenic (high reliable - CAESAR), possible non-mutagenic (high reliable - SarPy/IRFMN), non-mutagenic (moderate reliable - ISS) and non-mutagenic (high reliable - KNN/Read-Across).
Derek Nexus and Sarah Nexus were in agreement providing a negative prediction.
Therefore, it was concluded that 2-Benzyl-4-(dimethylamino)butanoic acid was predicted with a high level of confidence as negative.
Additional information
The prediction was provided on the substance2-Benzyl-4-(dimethylamino)butanoic acid (CAS 1613 -23 -6), the acid form of the substance in the object of the registration.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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