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EC number: 208-048-6 | CAS number: 506-64-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 July 2014 to 24 July 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as an unpublished report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Silver cyanide
- EC Number:
- 208-048-6
- EC Name:
- Silver cyanide
- Cas Number:
- 506-64-9
- Molecular formula:
- CAgN
- IUPAC Name:
- silver(1+) cyanide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material: silver cyanide
- Substance type: white powder
- Physical state: solid
- Stability under test conditions: At least 2 years, if stored correctly.
- Storage condition of test material: At room temperature in a tightly closed container.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CD : Crl CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles river Laboratories, Research Models and Services, Sulzfeld, Germany
- Age at study initiation: approx. 8 weeks
- Weight at study initiation: 230 - 281 g (males), 222 - 250 g (females)
- Fasting period before study: Yes, approximetely 16 hours before test item administration.
- Housing: Rats kept individually in MAKROLON cages (type III plus), with granulated textured wood (Granulat A2, J. Brandenburg, Germany) used as bedding material.
- Diet (e.g. ad libitum): Commercial diet, ssniff® R/M-H V1534 (ssniff Spezialdiäten GmbH, 59494 Soest, German)
- Water (e.g. ad libitum): tap water offered ad libitum
- Acclimation period:At least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 3°C
- Humidity (%): 55% ± 15%
- Photoperiod (hrs dark / hrs light):12 h light / 12 h dark (about 150 lux at approx. 1.50 m room height)
IN-LIFE DATES: From: 17 July 2014 To: 24 July 2014
Administration / exposure
- Vehicle:
- water
- Remarks:
- Aqua ad iniectabilia
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 5 x 6 cm
- % coverage: approx. 10 % of body surface
- Type of wrap if used: The test item was applied to 8 layers of gauze. The gauze was covered with a plastic sheet and secured with adhesive plaster on the application site.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No.
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3000 mg/kg b.w. of the paste (test item-vehicle preparation) (based on the weight)
- Concentration (if solution): 2000 mg/kg b.w.
- Constant volume or concentration used: No
- For solids, paste formed: yes, 10 g test item was mixed with 5 g water in a mortar to obtain a paste. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg b.w. (limit test)
- No. of animals per sex per dose:
- 5 rats per sex per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed before and immediately, 5, 15, 30 and 60 min, as well as 3, 6 and 24 hours after administration.
- Necropsy of survivors performed: yes
- Other examinations performed: changes of skin and fur, eyes and mucous membranes, respiratory and circulatory function, autonomic and central nervous system and somatomotor activity as well as behaviour pattern, were observed at least once a day until all symptoms subsided, thereafter each working day.Observations on mortality were made at least once daily to minimize loss of animals during the study. Individual body weights were recorded before administration of the test item and thereafter in weekly intervals up to the end of the study. Changes in weight were calculated and recorded.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- male/female
- Dose descriptor:
- LDLo
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortalities observed.
- Clinical signs:
- other: None.
- Gross pathology:
- None.
- Other findings:
- None.
Any other information on results incl. tables
Table 1. Summary of the results
Symptoms/criteria |
Silver cyanide 2000 mg/kg b.w. (n=5) |
|
males |
females |
|
Clinical signs |
None |
None |
Skin reaction |
None |
None |
Mortality within 6 h |
0 |
0 |
24 h |
0 |
0 |
7 d |
0 |
0 |
14 d |
0 |
0 |
Mean bodyweight (g) start |
257.8 |
230.6 |
After 7 d |
303.8 (+17.8) |
236.4 (+2.5) |
After 14 d |
364.0 (+41.2) |
255.8 (+10.9) |
Inhibition of bodyweight gain |
None |
None |
Necropsy findings |
None |
None |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Silver cyanide requires no labelling according to the EC directive 67/548/EEC. According to the EC Regulation 1272/2008 and Globally Harmonized Classification System (GHS), the test material is not classified for acute dermal toxicity.
- Executive summary:
Introduction
Silver cyanide was examined for acute toxicity after a single dermal application to rats. The study was conducted according to OECD 402 and EC method B.3.
Materials and methods
Silver cyanide was applied once for 24 hours on the shaved intact dorsal skin of rats. One dose level of 2000 mg/kg b.w. was used.
The treatment was followed by an observation period of 2 weeks.
Results
Under the present test conditions, a single dermal administration of 2000 mg silver cyanide/kg b.w. did not reveal any signs of toxicity. No animal died prematurely. All animals gained the expected weight throughout the whole experimental period. No macroscopic findings were observed at necropsy.
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