Registration Dossier
Registration Dossier
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EC number: 216-305-9 | CAS number: 1555-58-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity data List V
- Author:
- Smyth Jr H.F., Carpenter C.P., Weil C.S., Pozzani U.C.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. 10, 61-68 (1954)
Materials and methods
- Principles of method if other than guideline:
- The primary skin irritation potential of the test substance was assessed on 5 albino rabbits within 24 hours of application.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-(methylimino)bispropiononitrile
- EC Number:
- 216-305-9
- EC Name:
- 3,3'-(methylimino)bispropiononitrile
- Cas Number:
- 1555-58-4
- Molecular formula:
- C7H11N3
- IUPAC Name:
- 3-[(2-cyanoethyl)(methyl)amino]propanenitrile
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in publication: N-Methyl-3,3'-iminodipropionitrile
Test animals
- Species:
- rabbit
- Strain:
- other: Albino not further specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Undiluted, water, propylene glycol, or kerosene
- Controls:
- no
- Amount / concentration applied:
- 0.01 mL in concentrations ranging from 0.01 % to 100%
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- SCORING SYSTEM:Effects were graded on a scale from 1 to 10. Grade 1 indicates the least visible capillary injection from undiluted chemical. Grade 6 indicate necrosis when undiluted. Grade 10 indicates necrosis from a 0.01 % solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Grade
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 10
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test substance scored grade 1 out of 10. Indicating the least visible capillary injection from undiluted chemical.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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