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EC number: 695-076-0 | CAS number: 1334513-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 November 2012-11 January 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- EC Number:
- 695-076-0
- Cas Number:
- 1334513-02-8
- Molecular formula:
- C18H17F5NO5P
- IUPAC Name:
- Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test item
- Identification: GS-606962
- Description: White powder
- Substance type: organic
- Lot/batch No.: PSI-172(2)-1-1-12001
- Storage condition of test material: room temperature in the dark
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.13 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- other: 100% v/v saturated solution
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 0.13 mg/L
- Nominal / measured:
- meas. (TWA)
- Conc. based on:
- other: 100% v/v saturated solution
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Based on the time-weighted mean measured test concentration of the test media, the acute toxicity of the test item to rainbow trout (Oncorhynchus mykiss) gave a 96-Hour LC50 value greater than 0.13 mg/L. The No Observed Effect Concentration was 0.13 mg/L.
- Executive summary:
Introduction
A study was performed to assess the acute toxicity of the test item to rainbow trout (Oncorhynchus mykiss). The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (1992) No 2013, "Fish, Acute Toxicity Test" referenced as Method C.1 of Commission Regulation (EC) No. 440/2008.
Methods
Pre-study solubility work indicated that it was not possible to obtain a testable solution of the test item using traditional methods of dispersal, e.g. ultrasonication and high shear mixing.
A pre-study media preparation trial indicated that a dissolved test item concentration of approximately 0.17 mg/L could be obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of the test item under test conditions.
Following a preliminary range-finding test, seven fish were exposed to an aqueous solution of the test item at a single nominal concentration of 100% v/v saturated solution for a period of 96 hours at a temperature of 13°C to 15°C under semi-static test conditions. The test item solution was prepared by stirring an excess (50 mg/L) of test item in test medium using a propeller stirrer at approximately 1500 rpm for 24 hours. After the stirring period any undissolved test item was removed by filtration (0.2 µm Sartorius Sartopore filter, first approximate 2 liters discarded in order to pre-condition the filter) to produce a 100% v/v saturated solution of the test item. The number of mortalities and any sub-lethal effects of exposure and then daily throughout the test until termination after 96 hours.
Results
Analysis of the freshly prepared 100% v/v saturated solution test concentration at 0 and 72 hours ahowed measured test concentrations of 0.22 and 0.15 mg/L respectively. Analysis of the old or expired media at 24 and 96 hours showed measured concentrations had declined to 0.090 and 0.083 mg/L respectively.
Given this decline in measured test concentrations it was considered justifiable to base the results on the time-weighted mean measured test concentrations of the test media to give a "worst case" analysis of the data.
The 96 -Hour LC50 based on the time-weighted mean measured test concentration was greater than 0.13 mg/L. The No Observed Effect Concentration was 0.13 mg/L.
This study showed that there were no toxic effects of the test item at the limit of solubility.
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