Registration Dossier
Registration Dossier
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EC number: 245-890-3 | CAS number: 23787-90-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Exposure of Daphnia magna to the test item has been investigated and gave the following results based on the 0-Hour measured test concentrations (which remained stable over the 48h exposure period):
The 48 h EC50 was 5.3 mg/L with 95 % confidence limits of 3.7 - 6.7 mg/L
The No Observed Effect Concentration after 48 hours exposure was 3.7 mg/L.
The Lowest Observed Effect Concentration after 24 and 48 hours exposure was 6.7 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.2 mg/L
Additional information
A study was performed to assess the acute toxicity of the test item to Daphnia magna according to OECD Guidelines for Testing of Chemicals No 202, using an acute immobilisation test.
A preliminary media preparation trial indicated that a dissolved test item concentration of approximately 18 mg/L was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this item under test conditions.
The test item solutions were prepared by stirring an excess of test item in test water using a propeller stirrer at approximately 1500 rpm for 24 hours. After the stirring period, any undissolved test item was removed by filtration. The exposure was run under static conditions.
Analysis of the test preparations at 0 hours showed measured test concentrations to range from 3.70 to 19.2 mg/L. There was no significant change in the measured concentrations at 48 hours and so the results are based on 0-Hour measured test concentrations only. Exposure solutions were between 83.5 -95.8% of the time 0 starting concentrations at 48 hrs.
All validity criteria were met (0% immobilisation and no sub-lethal effects observed in the Control, and dissolved oxygen concentrations at the end of the test were all >3 mg/L)
The 48 h EC50 was 5.2 mg/L with 95 % confidence limits of 3.7 - 6.7 mg/L. The NOEC was 3.7 mg/L and the LOEC was 6.7 mg/L.
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